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2.A.1.2.33 The Hol1 MFS transporter (Mutation allows the uptake of histidinol and other cations (Wright et al., 1996). The N-terminal 200 residues show 22% identity with 2.A.1.2.1 and 2.A.1.2.16).
Accession Number:	P53389
Protein Name:	Protein Hol1
Length:	586
Molecular Weight:	65348.00
Species:	Saccharomyces cerevisiae (Baker's yeast) [4932]
Number of TMSs:	11
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate

DIP:	DIP-7266N
RefSeq:	NP_014453.1
Entrez Gene ID:	855792
Pfam:	PF07690
KEGG:	sce:YNR055C
Gene Ontology GO:0016021 C:integral to membrane GO:0005739 C:mitochondrion GO:0015665 F:alcohol transmembrane transporter activity GO:0022890 F:inorganic cation transmembrane transporter ... GO:0006812 P:cation transport GO:0015850 P:organic alcohol transport GO:0055085 P:transmembrane transport
References (3) [1] “Amino acid substitutions in membrane-spanning domains of Hol1, a member of the major facilitator superfamily of transporters, confer nonselective cation uptake in Saccharomyces cerevisiae.” Wright M.B.et.al. 8955402 [2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.” Philippsen P.et.al. 9169873 [3] “A global topology map of the Saccharomyces cerevisiae membrane proteome.” Kim H.et.al. 16847258

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MDKYTNRDHP DYIPGTFNIY SSQNLENGII YESKLKKTSS GVVLIPQPSY SPNDPLNWSS 
61:	WRKLAHFGLM AFITAFTAAT SNDAGAAQDS LNEIYGISYD SMNTGAGVLF LGIGWSTLFL 
121:	APFANLYGRK ITYIVCTTLG LFGALWFALA KRTSDTIWSQ LFVGISESCA EAQVQLSLSD 
181:	IFFQHQLGSV LTVYIMCTSI GTFLGPLIAG YISAFTNFRW VGWVAVIISG GLLITIIFGC 
241:	EETYFDRGQY MTPLTSCQSG YEDGTTLQNS DNTAVSRRKR HLDAKLSTPG AMGEKGVDLS 
301:	ETAEFEVNNE EEVTIPETRE LIDGSKEHLK PYPKRVAILT KATNLKGYGF KQYFKYLKIN 
361:	LRMFLFPPVW LSGMFWGIQD VFLTFYLTTQ ESAYYEPPWN YSDFGVAIMN VPTLIGAVIG 
421:	CICAGIVSDY FVLWMARHNR GILEAEFRLY FSIATAIIGP AGLLMFGIGT ARQWPWQAIY 
481:	VGLGFVGFAW GCSGDIAMAY LMDCYPDMVL EGMVCTAIIN NTISCIFTFT CSDWLAASGT 
541:	ENTYIALAVI NFGITAFALP MYYYGKRIRL WTKRWYLQSV NLRDGV

2.A.1.2.33
The Hol1 MFS transporter (Mutation allows the uptake of histidinol and other cations (Wright et al., 1996). The N-terminal 200 residues show 22% identity with 2.A.1.2.1 and 2.A.1.2.16).

Cross database links:

Gene Ontology

References (3)

External Searches:

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2.A.1.2.33The Hol1 MFS transporter (Mutation allows the uptake of histidinol and other cations (Wright et al., 1996). The N-terminal 200 residues show 22% identity with 2.A.1.2.1 and 2.A.1.2.16).

Cross database links:

Gene Ontology

References (3)

External Searches:

Analyze:

2.A.1.2.33
The Hol1 MFS transporter (Mutation allows the uptake of histidinol and other cations (Wright et al., 1996). The N-terminal 200 residues show 22% identity with 2.A.1.2.1 and 2.A.1.2.16).