2.A.1.2.51
Chloramphenicol resistance pump, CraA (43% identical to MdfA of E. coli) (Roca et al., 2009). It is a broad specificity transporter exporting chloramphenicol, thiamphenicol, florfenicol, ethidium, dequalinium, chlorhexidine, benzalkonium, mitomycin C and TPP+. Glu-38 is essential for activity (Foong et al. 2019).
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| Accession Number: | D0CCT2 |
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| Protein Name: | Chloramphenicol resistance protein CraA |
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| Length: | 413 |
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| Molecular Weight: | 45882.00 |
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| Species: | Acinetobacter baumannii (strain ATCC 19606 / DSM 30007 / CIP 70.34 / JCM 6841 / NBRC 109757 / NCIMB 12457 / NCTC 12156 / 81) [575584] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
chloramphenicol, benzalkonium chloride, florfenicol, thiamphenicol, ethidium, chlorhexidine |
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1: MYKLMKNIQT TALNRTTLMF PLALVLFEFA VYIGNDLIQP AMLAITEDFG VSATWAPSSM
61: SFYLLGGASV AWLLGPLSDR LGRKKVLLSG VLFFALCCFL ILLTRQIEHF LTLRFLQGIG
121: LSVISAVGYA AIQENFAERD AIKVMALMAN ISLLAPLLGP VLGAFLIDYV SWHWGFVAIA
181: LLALLSWVGL KKQMPSHKVS VTKQPFSYLF DDFKKVFSNR QFLGLTLALP LVGMPLMLWI
241: ALSPIILVDE LKLTSVQYGL AQFPVFLGLI VGNIVLIKII DRLALGKTVL IGLPIMLTGT
301: LILILGVVWQ AYLIPCLLIG MTLICFGEGI SFSVLYRFAL MSSEVSKGTV AAAVSMLLMT
361: SFFAMIELVR YLYTQFHLWA FVLSAFAFIA LWFTQPRLAL KREMQERVAQ DLH