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|---|---|
| Accession Number: | Q96BI1 |
| Protein Name: | Solute carrier family 22 member 18 |
| Length: | 424 |
| Molecular Weight: | 44846.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Apical cell membrane1 / Multi-pass membrane protein2 |
| Substrate | drug |
Cross database links:
| Entrez Gene ID: | 5002 |
|---|---|
| Pfam: | PF07690 |
| KEGG: | hsa:5002 hsa:5002 |
Gene Ontology
GO:0016324
C:apical plasma membrane
GO:0044444
C:cytoplasmic part
GO:0016021
C:integral to membrane
GO:0005635
C:nuclear envelope
GO:0015238
F:drug transmembrane transporter activity
GO:0015293
F:symporter activity
GO:0031625
F:ubiquitin protein ligase binding
GO:0007588
P:excretion
GO:0015695
P:organic cation transport
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References (16)[1] “Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.” Lee M.P.et.al. 9751628 [2] “A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.” Morisaki H.et.al. 9802569 [3] “Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain.” Cooper P.R.et.al. 9570947 [4] “IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes.” Dao D.et.al. 9499412 [5] “Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.” Schwienbacher C.et.al. 9520460 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Functional characterization of ORCTL2 -- an organic cation transporter expressed in the renal proximal tubules.” Reece M.et.al. 9744804 [8] “Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.” Yamada H.Y.et.al. 16314844 [9] “Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.” Lee M.P.et.al. 9751628 [10] “A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.” Morisaki H.et.al. 9802569 [11] “Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain.” Cooper P.R.et.al. 9570947 [12] “IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes.” Dao D.et.al. 9499412 [13] “Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples.” Schwienbacher C.et.al. 9520460 [14] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MQGARAPRDQ GRSPGRMSAL GRSSVILLTY VLAATELTCL FMQFSIVPYL SRKLGLDSIA 61: FGYLQTTFGV LQLLGGPVFG RFADQRGARA ALTLSFLAAL ALYLLLAAAS SPALPGVYLL 121: FASRLPGALM HTLPAAQMVI TDLSAPEERP AALGRLGLCF GVGVILGSLL GGTLVSAYGI 181: QCPAILAALA TLLGAVLSFT CIPASTKGAK TDAQAPLPGG PRASVFDLKA IASLLRLPDV 241: PRIFLVKVAS NCPTGLFMVM FSIISMDFFQ LEAAQAGYLM SFFGLLQMVT QGLVIGQLSS 301: HFSEEVLLRA SVLVFIVVGL AMAWMSSVFH FCLLVPGLVF SLCTLNVVTD SMLIKAVSTS 361: DTGTMLGLCA SVQPLLRTLG PTVGGLLYRS FGVPVFGHVQ VAINTLVLLV LWRKPMPQRK 421: DKVR