Search TCDB: (?)
TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.1.2.63
Probable drug/proton antiporter YHK8

Accession Number:P38776
Protein Name:Probable drug/proton antiporter YHK8
Length:514
Molecular Weight:57838.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate hydron, drug

Cross database links:

DIP: DIP-8197N
Entrez Gene ID: 856444   
Pfam: PF07690   
KEGG: sce:YHR048W   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0015297 F:antiporter activity
GO:0015893 P:drug transport
GO:0015992 P:proton transport

References (4)

[1] “Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII.”  Johnston M.et.al.   8091229
[2] “Identification of genes differentially expressed in association with reduced azole susceptibility in Saccharomyces cerevisiae.”  Barker K.S.et.al.   12697649
[3] “Evolution of gene families: the multidrug resistance transporter genes in five related yeast species.”  Gbelska Y.et.al.   16630275
[4] “A global topology map of the Saccharomyces cerevisiae membrane proteome.”  Kim H.et.al.   16847258

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MVAEFQIASA QSSALTSTEE EHCSINSDKA AKLDLELTSE RKNDGKQSHE VTFNEDIADP 
61:	EDIARHMSTA RRYYISSLIT FTSMVITMIS SSWTLPSTHI IEHFHISHEV STLGITLYVF 
121:	GLGIGPLFLS PLSELYGRRI TFLYALTLSI IWQCLTIWSK TITGVMFGRF LSGFFGSAFL 
181:	SVAGGAIADI FDKDQIGIPM AIYTTSAFLG PSLGPIIGGA LYHQSYKWTF ITLLITSGCC 
241:	LVMIIFTIPE TYKPMLLIRK AKRLRKEKND QRYYAVLEVT REQTSLLSAI FLSTKRPFGL 
301:	LLRDRMMGVL CFYTGLELAI IYLYFVAFPY VFKKLYNFGP MEIACSYIGI MVGMILSAPT 
361:	CLLFQKTFEW RVKRNNGVKT PEMRFEPLFY GAFLTPVGLF IFAFTCYKHV HWIAPIIGSA 
421:	IFGSGVYFVF TGVFAYTVDA YRRYAASGMA CNTFVRCIMA GVFPLFGLQM YKSMGVNWAG 
481:	FLLAMVTVAM IPVPFLFTKY GARLRAKSPY AWDD