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|---|---|
| Accession Number: | P02980 |
| Protein Name: | Tetracycline resistance protein, class B |
| Length: | 401 |
| Molecular Weight: | 43267.00 |
| Species: | Escherichia coli [562] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Cell inner membrane1 / Multi-pass membrane protein2 |
| Substrate | tetracycline |
Cross database links:
| DIP: | DIP-16933N |
|---|---|
| Entrez Gene ID: | 4924775 |
| Pfam: | PF07690 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0015297
F:antiporter activity
GO:0046677
P:response to antibiotic
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References (5)[1] “Sequence homology between the tetracycline-resistance determinants of Tn10 and pBR322.” Nguyen T.T.et.al. 6319234 [2] “Nucleotide sequence of the Tn10 encoded tetracycline resistance gene.” Hillen W.et.al. 6298728 [3] “Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon Tn10. Histidine 257 plays an essential role in H+ translocation.” Yamaguchi A.et.al. 1848846 [4] “Metal-tetracycline/H+ antiporter of Escherichia coli encoded by a transposon, Tn10. The role of the conserved dipeptide, Ser65-Asp66, in tetracycline transport.” Yamaguchi A.et.al. 2168416 [5] “Membrane topology of the transposon 10-encoded metal-tetracycline/H+ antiporter as studied by site-directed chemical labeling.” Kimura T.et.al. 8995300
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MNSSTKIALV ITLLDAMGIG LIMPVLPTLL REFIASEDIA NHFGVLLALY ALMQVIFAPW 61: LGKMSDRFGR RPVLLLSLIG ASLDYLLLAF SSALWMLYLG RLLSGITGAT GAVAASVIAD 121: TTSASQRVKW FGWLGASFGL GLIAGPIIGG FAGEISPHSP FFIAALLNIV TFLVVMFWFR 181: ETKNTRDNTD TEVGVETQSN SVYITLFKTM PILLIIYFSA QLIGQIPATV WVLFTENRFG 241: WNSMMVGFSL AGLGLLHSVF QAFVAGRIAT KWGEKTAVLL GFIADSSAFA FLAFISEGWL 301: VFPVLILLAG GGIALPALQG VMSIQTKSHQ QGALQGLLVS LTNATGVIGP LLFAVIYNHS 361: LPIWDGWIWI IGLAFYCIII LLSMTFMLTP QAQGSKQETS A