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2.A.1.2.73
Major facilitator superfamily domain-containing protein 10, MFSD10, a member of the SLC18 family. It is a tetracycline exporter-like protein.  This protein is found in the inner nuclear membrane (Cheng et al. 2019) and is a disease protein in humans (Bagchi et al. 2020). Its gene shows increased expression with increased energy consumption (Bagchi et al. 2020). It may confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs, indomethacin and diclofenac. A microdeletion proximal to the mfsD10 gene is associated with mild Wolf-Hirschhorn syndrome (Hannes et al. 2012).
 

Accession Number:Q9D2V8
Protein Name:Major facilitator superfamily domain-containing protein 10
Length:456
Molecular Weight:49369.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate tetracycline

Cross database links:

Entrez Gene ID: 68294   
Pfam: PF07690   
KEGG: mmu:68294   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005215 F:transporter activity
GO:0006915 P:apoptotic process
GO:0055085 P:transmembrane transport

References (2)

[1] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGWAGDAGCT PRPPIRPRPA SERRVIIVLF LGLLLDLLAF TLLLPLLPGL LERHGREQDP 
61:	LYGSWQRGVD WFASAIGMPA EKRYNSVLFG GLIGSAFSLL QFFSAPLTGA ASDYLGRRPV 
121:	MMLSLTGLAI SYAVWATSRS FKAFLASRVI GGISKGNVNL STAIVADLGS PPTRSQGMAV 
181:	IGVAFSLAFT LGPMLGAFLS VEMVPWISLL FAISDMLFIF CFLPETLPQE KRASSVTLGF 
241:	HTAAHLLSPL ALLRFAAVTH SQDPPAEHRL RNLRRLGLVY FLYLFLFSGL EYTLSFLAHQ 
301:	RFQFSSLQQG KMFFFIGLTM ATIQGTYARR ISPGKEAAAV TRAMLLLVPA FLLIGWAHSL 
361:	PTLGLGLMLY SFAAAVVVPG LSTMVSSYGS PGQKGTIMGI LRSLGALGRA LGPVVAASVY 
421:	WLTGAQVCFT VCSALFLLPF LLLWKLKHPA ETSKEE