2.A.1.2.97
Bcr/CflA family drug exporter, MSMEG_2991 of 428 aas and 12 TMSs. A pmf-dependent multidrug efflux pump that expels diverse groups of antibiotics including ciprofloxacin. May also be involved in biofilm enhancement (Bansal et al. 2016).
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| Accession Number: | I7FD23 |
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| Protein Name: | Drug resistance transporter, Bcr/CflA family |
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| Length: | 428 |
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| Molecular Weight: | 43537.00 |
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| Species: | Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) [246196] |
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| Number of TMSs: | 12 |
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| Substrate |
ciprofloxacin, drug |
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1: MMRIRTAAPG TTTPTLALII LLALLNAVTP FSVDMYMSAF PAMAVEFGTS ASVVQLTLTT
61: FLIGLATGQL FIGQLSDRLG RRGPLLVGIV ACLVASLLCA VSPSIEVLIM LRFVQGFAGA
121: AGIVIARAII SDRSKGSQAA KLYSVMMVIG VLAPILAPVL GGQVVAGFGW RAVFLALAGL
181: NLVMLLGALF MAGESLPPEA RRPAGLKAFA GSAASVLTNR RFMGYTLTLS CSGAAMFSYI
241: SASPFVLQNI IGLSPRAFSF TFGGCALAVA VSGVISARLV GRFGPRKLLL GGVSAMVVVA
301: ALMLLNVTVG GVVPAVTVAL MACFMGTVGF TFANATTLAI GEVRHAAGTG SAVIGFLQYG
361: LGAVASPLVG LAGEHSAVPM GVAMFTCAAL AATALLVLTR GHIPSYDDEL ADLDADLTAV
421: SAGESTAR