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2.A.1.20.2 Sugar efflux system, SetB, for lactose and glucose, but not IPTG or galactose (Liu et al. 1999). Overexpression of the gene for SetB allows export of Lacto-N-triose (LNT II) and lacto-N-tetraose (LNT), human milk oligosaccharides (Sugita and Koketsu 2022).
Accession Number:	P33026
Protein Name:	SetB aka YeiO aka B2170
Length:	393
Molecular Weight:	42746.00
Species:	Escherichia coli [83333]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	oligosaccharide, trisaccharide, alpha-lactose, glucose

RefSeq:	AP_002767.1 NP_416675.1
Entrez Gene ID:	946673
Pfam:	PF07690
BioCyc:	EcoCyc:B2170-MONOMER ECOL168927:B2170-MONOMER
KEGG:	ecj:JW2157 eco:b2170
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015542 F:sugar efflux transmembrane transporter acti... GO:0007059 P:chromosome segregation GO:0015758 P:glucose transport GO:0015767 P:lactose transport GO:0055085 P:transmembrane transport
References (5) [1] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.” Itoh T.et.al. 9097040 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “The identification of a new family of sugar efflux pumps in Escherichia coli.” Liu J.Y.et.al. 10209755 [5] “Functional and biochemical characterization of Escherichia coli sugar efflux transporters.” Liu J.Y.et.al. 10438463

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CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MHNSPAVSSA KSFDLTSTAF LIVAFLTGIA GALQTPTLSI FLTDEVHARP AMVGFFFTGS 
61:	AVIGILVSQF LAGRSDKRGD RKSLIVFCCL LGVLACTLFA WNRNYFVLLF VGVFLSSFGS 
121:	TANPQMFALA REHADKTGRE AVMFSSFLRA QVSLAWVIGP PLAYALAMGF SFTVMYLSAA 
181:	VAFIVCGVMV WLFLPSMRKE LPLATGTIEA PRRNRRDTLL LFVICTLMWG SNSLYIINMP 
241:	LFIINELHLP EKLAGVMMGT AAGLEIPTML IAGYFAKRLG KRFLMRVAAV GGVCFYAGML 
301:	MAHSPVILLG LQLLNAIFIG ILGGIGMLYF QDLMPGQAGS ATTLYTNTSR VGWIIAGSVA 
361:	GIVAEIWNYH AVFWFAMVMI IATLFCLLRI KDV

2.A.1.20.2
Sugar efflux system, SetB, for lactose and glucose, but not IPTG or galactose (Liu et al. 1999). Overexpression of the gene for SetB allows export of Lacto-N-triose (LNT II) and lacto-N-tetraose (LNT), human milk oligosaccharides (Sugita and Koketsu 2022).

Cross database links:

Gene Ontology

References (5)

External Searches:

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2.A.1.20.2Sugar efflux system, SetB, for lactose and glucose, but not IPTG or galactose (Liu et al. 1999). Overexpression of the gene for SetB allows export of Lacto-N-triose (LNT II) and lacto-N-tetraose (LNT), human milk oligosaccharides (Sugita and Koketsu 2022).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

2.A.1.20.2
Sugar efflux system, SetB, for lactose and glucose, but not IPTG or galactose (Liu et al. 1999). Overexpression of the gene for SetB allows export of Lacto-N-triose (LNT II) and lacto-N-tetraose (LNT), human milk oligosaccharides (Sugita and Koketsu 2022).