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2.A.1.21.12 Multidrug-efflux transporter, Rv1258c/MT1297, of 419 aas and 12 TMSs. Both Rv1634 and Rv1258c are believed to play major roles in drug resistance by altering the protein pump that is required to remove the active drugs from the bacterial cell (Panja et al. 2019).
Accession Number:	P64783
Protein Name:	Probable multidrug-efflux transporter Rv1258c/MT1297
Length:	419
Molecular Weight:	43287.00
Species:	Mycobacterium tuberculosis [1773]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell membrane¹ / Multi-pass membrane protein²
Substrate	drug

Entrez Gene ID:	887056 924773
Pfam:	PF07690
KEGG:	mtc:MT1297 mtu:Rv1258c
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015562 F:efflux transmembrane transporter activity GO:0046677 P:response to antibiotic
References (4) [1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.” Cole S.T.et.al. 9634230 [2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.” Fleischmann R.D.et.al. 12218036 [3] “The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.” De Rossi E.et.al. 12520088 [4] “Mycobacterium tuberculosis isolate with a distinct genomic identity overexpresses a tap-like efflux pump.” Siddiqi N.et.al. 15057575

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MRNSNRGPAF LILFATLMAA AGDGVSIVAF PWLVLQREGS AGQASIVASA TMLPLLFATL 
61:	VAGTAVDYFG RRRVSMVADA LSGAAVAGVP LVAWGYGGDA VNVLVLAVLA ALAAAFGPAG 
121:	MTARDSMLPE AAARAGWSLD RINGAYEAIL NLAFIVGPAI GGLMIATVGG ITTMWITATA 
181:	FGLSILAIAA LQLEGAGKPH HTSRPQGLVS GIAEGLRFVW NLRVLRTLGM IDLTVTALYL 
241:	PMESVLFPKY FTDHQQPVQL GWALMAIAGG GLVGALGYAV LAIRVPRRVT MSTAVLTLGL 
301:	ASMVIAFLPP LPVIMVLCAV VGLVYGPIQP IYNYVIQTRA AQHLRGRVVG VMTSLAYAAG 
361:	PLGLLLAGPL TDAAGLHATF LALALPIVCT GLVAIRLPAL RELDLAPQAD IDRPVGSAQ

2.A.1.21.12
Multidrug-efflux transporter, Rv1258c/MT1297, of 419 aas and 12 TMSs. Both Rv1634 and Rv1258c are believed to play major roles in drug resistance by altering the protein pump that is required to remove the active drugs from the bacterial cell (Panja et al. 2019).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

2.A.1.21.12Multidrug-efflux transporter, Rv1258c/MT1297, of 419 aas and 12 TMSs. Both Rv1634 and Rv1258c are believed to play major roles in drug resistance by altering the protein pump that is required to remove the active drugs from the bacterial cell (Panja et al. 2019).

Cross database links:

Gene Ontology

References (4)

External Searches:

Analyze:

2.A.1.21.12
Multidrug-efflux transporter, Rv1258c/MT1297, of 419 aas and 12 TMSs. Both Rv1634 and Rv1258c are believed to play major roles in drug resistance by altering the protein pump that is required to remove the active drugs from the bacterial cell (Panja et al. 2019).