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| Accession Number: | O00400 |
| Protein Name: | Acetyl-coenzyme A transporter |
| Length: | 549 |
| Molecular Weight: | 60909.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
| Substrate | coenzyme A, acetyl-CoA |
Cross database links:
| RefSeq: | NP_004724.1 |
|---|---|
| Entrez Gene ID: | 9197 |
| Pfam: | PF13000 |
| OMIM: |
603690 gene 612539 phenotype |
| KEGG: | hsa:9197 hsa:9197 |
Gene Ontology
GO:0005789
C:endoplasmic reticulum membrane
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0008521
F:acetyl-CoA transporter activity
GO:0008219
P:cell death
GO:0006810
P:transport
GO:0000139
C:Golgi membrane
GO:0055085
P:transmembrane transport
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References (13)[1] “Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated gangliosides: a putative acetyl CoA transporter.” Kanamori A.et.al. 9096318 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976 [5] “The consensus coding sequences of human breast and colorectal cancers.” Sjoeblom T.et.al. 16959974 [6] “A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42).” Lin P.et.al. 19061983 [7] “Expression cloning and characterization of a cDNA encoding a novel membrane protein required for the formation of O-acetylated gangliosides: a putative acetyl CoA transporter.” Kanamori A.et.al. 9096318 [8] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [10] “Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.” Daub H.et.al. 18691976 [11] “The consensus coding sequences of human breast and colorectal cancers.” Sjoeblom T.et.al. 16959974 [12] “A missense mutation in SLC33A1, which encodes the acetyl-CoA transporter, causes autosomal-dominant spastic paraplegia (SPG42).” Lin P.et.al. 19061983 [13] “Mutations in SLC33A1 cause a lethal autosomal-recessive disorder with congenital cataracts, hearing loss, and low serum copper and ceruloplasmin.” Huppke P.et.al. 22243965
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSPTISHKDS SRQRRPGNFS HSLDMKSGPL PPGGWDDSHL DSAGREGDRE ALLGDTGTGD 61: FLKAPQSFRA ELSSILLLLF LYVLQGIPLG LAGSIPLILQ SKNVSYTDQA FFSFVFWPFS 121: LKLLWAPLVD AVYVKNFGRR KSWLVPTQYI LGLFMIYLST QVDRLLGNTD DRTPDVIALT 181: VAFFLFEFLA ATQDIAVDGW ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF 241: CNKYLRFQPQ PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ENEVSVVKEE TQGITDTYKL 301: LFAIIKMPAV LTFCLLILTA KIGFSAADAV TGLKLVEEGV PKEHLALLAV PMVPLQIILP 361: LIISKYTAGP QPLNTFYKAM PYRLLLGLEY ALLVWWTPKV EHQGGFPIYY YIVVLLSYAL 421: HQVTVYSMYV SIMAFNAKVS DPLIGGTYMT LLNTVSNLGG NWPSTVALWL VDPLTVKECV 481: GASNQNCRTP DAVELCKKLG GSCVTALDGY YVESIICVFI GFGWWFFLGP KFKKLQDEGS 541: SSWKCKRNN