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|---|---|
| Accession Number: | Q9UPI3 |
| Protein Name: | Feline leukemia virus subgroup C receptor-related protein 2 |
| Length: | 526 |
| Molecular Weight: | 57241.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
| Substrate | ferroheme b |
Cross database links:
| Entrez Gene ID: | 55640 |
|---|---|
| Pfam: | PF07690 |
| KEGG: | hsa:55640 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0020037
F:heme binding
GO:0015232
F:heme transporter activity
GO:0055085
P:transmembrane transport
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References (8)[1] “Novel hexad repeats conserved in a putative transporter with restricted expression in cell types associated with growth, calcium exchange and homeostasis.” Brasier G.et.al. 14729055 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “The DNA sequence and analysis of human chromosome 14.” Heilig R.et.al. 12508121 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “The Fowler syndrome-associated protein FLVCR2 is an importer of heme.” Duffy S.P.et.al. 20823265 [6] “Mutations in FLVCR2 are associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Fowler syndrome).” Meyer E.et.al. 20206334 [7] “Unexpected allelic heterogeneity and spectrum of mutations in Fowler syndrome revealed by next-generation exome sequencing.” Lalonde E.et.al. 20518025 [8] “High-throughput sequencing of a 4.1 Mb linkage interval reveals FLVCR2 deletions and mutations in lethal cerebral vasculopathy.” Thomas S.et.al. 20690116
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MVNEGPNQEE SDDTPVPESA LQADPSVSVH PSVSVHPSVS INPSVSVHPS SSAHPSALAQ 61: PSGLAHPSSS GPEDLSVIKV SRRRWAVVLV FSCYSMCNSF QWIQYGSINN IFMHFYGVSA 121: FAIDWLSMCY MLTYIPLLLP VAWLLEKFGL RTIALTGSAL NCLGAWVKLG SLKPHLFPVT 181: VVGQLICSVA QVFILGMPSR IASVWFGANE VSTACSVAVF GNQLGIAIGF LVPPVLVPNI 241: EDRDELAYHI SIMFYIIGGV ATLLLILVII VFKEKPKYPP SRAQSLSYAL TSPDASYLGS 301: IARLFKNLNF VLLVITYGLN AGAFYALSTL LNRMVIWHYP GEEVNAGRIG LTIVIAGMLG 361: AVISGIWLDR SKTYKETTLV VYIMTLVGMV VYTFTLNLGH LWVVFITAGT MGFFMTGYLP 421: LGFEFAVELT YPESEGISSG LLNISAQVFG IIFTISQGQI IDNYGTKPGN IFLCVFLTLG 481: AALTAFIKAD LRRQKANKET LENKLQEEEE ESNTSKVPTA VSEDHL