2.A.1.28.6 Electrogenic DIRC2 (Disrupted in renal carcinoma 2) or SLC49A4. It is glycosylated and proteolytically processed (Savalas et al., 2011)) and is targeted to lysosomes via an N-terminal dileueine motif. It is implicated in hereditary renal carcinomas (Khan and Quigley 2018). DIRC2 is an electrogenic lysosomal metabolite transporter which is
subjected to and presumably modulated by limited proteolytic processing (Savalas et al. 2011).
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Accession Number: | Q96SL1 |
Protein Name: | Disrupted in renal carcinoma protein 2 |
Length: | 478 |
Molecular Weight: | 52088.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 12 |
Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
Substrate |
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Entrez Gene ID: |
84925
|
KEGG: |
hsa:84925
|
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[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T. et.al. 14702039
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
[3] “Disruption of a novel MFS transporter gene, DIRC2, by a familial renal cell carcinoma-associated t(2;3)(q35;q21).” Bodmer D. et.al. 11912179
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1: MGSRWSSEEE RQPLLGPGLG PGLGASWRSR EAAAAALPAA VPGPGRVYGR RWLVLLLFSL
61: LAFVQGLVWN TWGPIQNSAR QAYGFSSWDI ALLVLWGPIG FLPCFAFMWL LDKRGLRITV
121: LLTSFLMVLG TGLRCIPISD LILKRRLIHG GQMLNGLAGP TVMNAAPFLS TTWFSADERA
181: TATAIASMLS YLGGACAFLV GPLVVPAPNG TSPLLAAESS RAHIKDRIEA VLYAEFGVVC
241: LIFSATLAYF PPRPPLPPSV AAASQRLSYR RSVCRLLSNF RFLMIALAYA IPLGVFAGWS
301: GVLDLILTPA HVSQVDAGWI GFWSIVGGCV VGIAMARFAD FIRGMLKLIL LLLFSGATLS
361: STWFTLTCLN SITHLPLTTV TLYASCILLG VFLNSSVPIF FELFVETVYP VPEGITCGVV
421: TFLSNMFMGV LLFFLTFYHT ELSWFNWCLP GSCLLSLLLI LCFRESYDRL YLDVVVSV