2.A.1.28.8
MFSD7, FLVCR2 or SLC49A3 of 560 aas and 12 TMSs. It is the feline leukemia virus subgroup C receptor-2 (FLVCR2), a member of the
SLC49 family of four paralogous genes in humans (Khan and Quigley 2018). It is a cell surface heme transporter,
essential for erythropoiesis and systemic iron homeostasis. Mutations of SLC49A2, encoding FLVCR1, are noted in patients with Fowler syndrome (Khan and Quigley 2018). FLVCR2 is 30% identical to FLVCR1 (TC# 2.A.1.28.1).
|
| Accession Number: | Q6UXD7 |
|---|
| Protein Name: | Solute carrier family 49 member A3 |
|---|
| Length: | 560 |
|---|
| Molecular Weight: | 58427.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 12 |
|---|
| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
ferroheme b |
|---|
1: MAGPTEAETG LAEPRALCAQ RGHRTYARRW VFLLAISLLN CSNATLWLSF APVADVIAED
61: LVLSMEQINW LSLVYLVVST PFGVAAIWIL DSVGLRAATI LGAWLNFAGS VLRMVPCMVV
121: GTQNPFAFLM GGQSLCALAQ SLVIFSPAKL AALWFPEHQR ATANMLATMS NPLGVLVANV
181: LSPVLVKKGE DIPLMLGVYT IPAGVVCLLS TICLWESVPP TPPSAGAASS TSEKFLDGLK
241: LQLMWNKAYV ILAVCLGGMI GISASFSALL EQILCASGHS SGFSGLCGAL FITFGILGAL
301: ALGPYVDRTK HFTEATKIGL CLFSLACVPF ALVSQLQGQT LALAATCSLL GLFGFSVGPV
361: AMELAVECSF PVGEGAATGM IFVLGQAEGI LIMLAMTALT VRRSEPSLST CQQGEDPLDW
421: TVSLLLMAGL CTFFSCILAV FFHTPYRRLQ AESGEPPSTR NAVGGADSGP GVDRGGAGRA
481: GVLGPSTATP ECTARGASLE DPRGPGSPHP ACHRATPRAQ GPAATDAPSR PGRLAGRVQA
541: SRFIDPAGSH SSFSSPWVIT