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| Accession Number: | O52557 |
| Protein Name: | RifP |
| Length: | 522 |
| Molecular Weight: | 53209.00 |
| Species: | Amycolatopsis mediterranei (Nocardia mediterranei) [33910] |
| Number of TMSs: | 14 |
| Location1 / Topology2 / Orientation3: | Cell inner membrane1 / Multi-pass membrane protein2 |
| Substrate | hydron, rifamycins, rifamycin SV |
Cross database links:
| Pfam: | PF07690 |
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Gene Ontology
GO:0016021
C:integral to membrane
GO:0015520
F:tetracycline:hydrogen antiporter activity
GO:0046677
P:response to antibiotic
GO:0015904
P:tetracycline transport
GO:0055085
P:transmembrane transport
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References (3)[1] “Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.” August P.R.et.al. 9512878 [2] “3-amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.” Kim C.G.et.al. 9497318 [3] “Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.” Yu T.W.et.al. 11278540
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MHATAAVTET RNPRRWLILA VISLAQLVVL VDNTVLNLAI PKLTEDLGAT TADIQWMINA 61: YALVQSGLLL TAGSFSDRYG RKRSLLAGLL LFGVGSLAAA FSLSSGQLIA ARAGMGIGGA 121: LLTTTTLAVV MQVFDEKELP KAIGLWSAVS SFGYASGPLI GGALLAHFWW GSIFLINIPV 181: ALLGCVAVAK LVPESKDPQG ARPDLVGAAL STIGMAGIVY AIISGPEHGW ASATVLVAAG 241: IGVAALAAFV RWELHVPHPM LDMGLFRNRR FNGAISGGLL VAFGMGGSVF LLTQQLQLVL 301: GYDPLEAGLR TAPLALVVVA LNVAGLGAKL LEKLGIAMTI AVGMTLNAVG LAMVAVLGTP 361: DRGFGGMLAC LLVMGGGIAP AMPAMANAIM TSIPAEKAGA GAAVQGTVNQ FGSGLGVAIL 421: GAVLNSRFAA LLPIGLGAGA AGSLHEALLQ ARTPALQAQV RDAFAGGVRA SELIGALAVV 481: LGGMLAGMLL RRAARSEAHQ AAWARPTIRL EAAPAPFTVD LR