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|---|---|
| Accession Number: | P36554 |
| Protein Name: | Inner membrane transport protein, YegB |
| Length: | 471 |
| Molecular Weight: | 50901.00 |
| Species: | Escherichia coli [83333] |
| Number of TMSs: | 14 |
| Location1 / Topology2 / Orientation3: | Cell inner membrane1 / Multi-pass membrane protein2 |
| Substrate | novobiocin, arabinose, deoxycholate |
Cross database links:
| DIP: | DIP-11876N |
|---|---|
| RefSeq: | AP_002677.1 NP_416581.1 |
| Entrez Gene ID: | 946601 |
| Pfam: | PF07690 |
| BioCyc: | EcoCyc:B2077-MONOMER ECOL168927:B2077-MONOMER |
| KEGG: | ecj:JW2062 eco:b2077 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0015520
F:tetracycline:hydrogen antiporter activity
GO:0046677
P:response to antibiotic
GO:0015904
P:tetracycline transport
GO:0055085
P:transmembrane transport
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References (7)[1] “The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.” Nagakubo S.et.al. 12107133 [2] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.” Itoh T.et.al. 9097040 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “Novel members of the two-component signal transduction genes in Escherichia coli.” Nagasawa S.et.al. 8282725 [6] “The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate.” Baranova N.et.al. 12107134 [7] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MTDLPDSTRW QLWIVAFGFF MQSLDTTIVN TALPSMAQSL GESPLHMHMV IVSYVLTVAV 61: MLPASGWLAD KVGVRNIFFT AIVLFTLGSL FCALSGTLNE LLLARALQGV GGAMMVPVGR 121: LTVMKIVPRE QYMAAMTFVT LPGQVGPLLG PALGGLLVEY ASWHWIFLIN IPVGIIGAIA 181: TLLLMPNYTM QTRRFDLSGF LLLAVGMAVL TLALDGSKGT GLSPLTIAGL VAVGVVALVL 241: YLLHARNNNR ALFSLKLFRT RTFSLGLAGS FAGRIGSGML PFMTPVFLQI GLGFSPFHAG 301: LMMIPMVLGS MGMKRIVVQV VNRFGYRRVL VATTLGLSLV TLLFMTTALL GWYYVLPFVL 361: FLQGMVNSTR FSSMNTLTLK DLPDNLASSG NSLLSMIMQL SMSIGVTIAG LLLGLFGSQH 421: VSVDSGTTQT VFMYTWLSMA LIIALPAFIF ARVPNDTHQN VAISRRKRSA Q