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2.A.1.3.48
Multidrug-efflux transporter Rv1634/MT1670 of 471 aas and 14 TMSs.  Both Rv1634 and Rv1258c are believed to play a major role in drug resistance by altering the protein pump that is required to remove the active drug compounds from the bacterial cell (Panja et al. 2019). Ciprofloxacin and norfloxacin are substrates, to which M. tuberculosis strains have become resistant. The expulsion of the drugs to the outside the bacterial cell occurs through the alternating-access mechanism of N and C-terminal domains (Singh and Akhter 2021).

Accession Number:O06151
Protein Name:Probable multidrug-efflux transporter Rv1634/MT1670
Length:471
Molecular Weight:47713.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:14
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate ciprofloxacin, norfloxacin, drug

Cross database links:

Entrez Gene ID: 885115    924194   
Pfam: PF07690   
KEGG: mtc:MT1670    mtu:Rv1634   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0015562 F:efflux transmembrane transporter activity
GO:0042891 P:antibiotic transport
GO:0046677 P:response to antibiotic

References (3)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[3] “The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.”  De Rossi E.et.al.   12520088

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTETASETGS WRELLSRYLG TSIVLAGGVA LYATNEFLTI SLLPSTIADI GGSRLYAWVT 
61:	TLYLVGSVVA ATTVNTMLLR VGARSSYLMG LAVFGLASLV CAAAPSMQIL VAGRTLQGIA 
121:	GGLLAGLGYA LINSTLPKSL WTRGSALVSA MWGVATLIGP ATGGLFAQLG LWRWAFGVMT 
181:	LLTALMAMLV PVALGAGGVG PGGETPVGST HKVPVWSLLL MGAAALAISV AALPNYLVQT 
241:	AGLLAAAALL VAVFVVVDWR IHAAVLPPSV FGSGPLKWIY LTMSVQMIAA MVDTYVPLFG 
301:	QRLGHLTPVA AGFLGAALAV GWTVGEVASA SLNSARVIGH VVAAAPLVMA SGLALGAVTQ 
361:	RADAPVGIIA LWALALLIIG TGIGIAWPHL TVRAMDSVAD PAESSAAAAA INVVQLISGA 
421:	FGAGLAGVVV NTAKGGEVAA ARGLYMAFTV LAAAGVIASY QATHRDRRLP R