2.A.1.3.59
MDR efflux pump, NorC (Truong-Bolduc et al. 2006). Proposed to be a quinolone resistance exporter, NorB (Marklevitz and Harris 2016). The 3-d x-ray structure at 3.6 Å resolution has been solved in an outward open configuration (Kumar et al. 2021). The structure shows that NorC specifically interacts with an organic cation, tetraphenylphosphonium. Multidrug-resistance in S. aureus is inhibited by the endocannabinoid, anandamide (Sionov et al. 2022).
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| Accession Number: | D1GUL7 |
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| Protein Name: | Putative transporter protein |
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| Length: | 462 |
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| Molecular Weight: | 48937.00 |
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| Species: | Staphylococcus aureus (strain TW20 / 0582) [663951] |
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| Number of TMSs: | 14 |
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| Substrate |
quinolone, diterpene |
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1: MNETYRGGNK LILGIVLGVI TFWLFAQSLV NVVPNLQQSF GADMGTISIA VSLTALFSGM
61: FVVGAGGLAD KIGRVKMTNI GLLLSIIGSA LIIITNLPAL LILGRIIQGV SAACIMPSTL
121: AIMKTYYEGA ERQRALSYWS IGSWGGSGIC SLFGGAVATT MGWRWIFIFS IIVAVLSMLL
181: IKGTPETKSE VTNTHKFDVA GLIVLVVMLL SLNVVITKGA ALGYTSLWFF GLIAIVIVAF
241: FIFLNVEKKV DNPLIDFKLF ENKPYTGATI SNFLLNGVAG TLIVANTFVQ QGLGYTALQA
301: GYLSITYLIM VLLMIRVGEK LLQKMGSKRP MLLGTFIVII GIALISLVFL PGIFYVISCV
361: VGYLCFGLGL GIYATPSTDT AISNAPLDKV GVASGIYKMA SSLGGAFGVA ISGAVYAGAV
421: AATSIHTGAM IALWVNVLMG IMAFIAILFA IPNDDKRVKD AK