2.A.1.3.61 MDR efflux pump, MdeA. Exports quaternary ammonium compounds and antibiotics (Huang et al. 2004). Also exports hoechst 33342, doxorubicin, daunorubicin, tetraphenyl phosphonium, ethidium bromide and rhodamine 6G (Yamada et al. 2006). Multidrug-resistance in S. aureus is inhibited by the endocannabinoid, anandamide (Sionov et al. 2022).
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Accession Number: | Q7A3S4 |
Protein Name: | SA2203 protein |
Length: | 479 |
Molecular Weight: | 52169.00 |
Species: | Staphylococcus aureus (strain N315) [158879] |
Number of TMSs: | 14 |
Substrate |
rhodamine 6G, quaternary ammonium salt, tetraphenylphosphonium, 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole, doxorubicin, daunorubicin, antimicrobial agent, ethidium bromide |
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1: MSKKQKLTMI ITMLMGGFFG LLNETLLVTA LPSIMKDFEI SYTQVQWLTT AFLLTNGIVI
61: PLSALVIQRY TTRQVFLVGI SIFFLGTLLG GLSPHFATLL VARIIQALGA GIMMPLMMTT
121: ILDVFQPHER GKYMGIFGLV IGLAPAIGPT LSGYLVEYLN WRSLFHVVAP IAAVTFLIGF
181: KTIKNVGTTI KVPIDFISVI FSVLGFGGLL YGTSSISEKG FDNPIVLVSM IGGVVLVALF
241: VLRQYRLSTP LLNFAVFKNK QFTVGIIIMG VTMVSMIGSE TILPIFVQNL LHRSALDSGL
301: TLLPGAIVMA FMSMTSGALY EKFGPRKLAL VGMAIVVITT AYFVVMDEQT STIMLATVYA
361: IRMVGIALGL IPVMTHTMNQ LKPEMNAHGS SMTNTVQQIA GSIGTAALIT ILSHASKNFS
421: PTMSDYNGMN KIDMMNQIKV DTMLHGYHAG FLFALLITVV SFFCSFMLQG KKKEVDSRQ