2.A.1.3.71
Putative multidrug-resistance exporter of 553 aas and 14 putative TMSs, KNQ1. It is a drug efflux permease for several toxic compounds that in
multiple copies confer increased dithiothreitol resistance. KNQ1 does not export dithiothreitol or function in recombinant protein secretion. KNQ1 gene amplification or deletion resulted in enhanced transcription of
iron transport genes, suggesting, a role
in iron homeostasis on which dithiothreitol tolerance may depend (Marchi et al. 2007).
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| Accession Number: | Q874B4 |
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| Protein Name: | Drug efflux permease KNQ1 |
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| Length: | 553 |
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| Molecular Weight: | 60192.00 |
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| Species: | Kluyveromyces lactis (Yeast) [28985] |
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| Number of TMSs: | 13 |
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| Substrate |
drug |
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1: MPSEKSVTFP KGSLFHQDTL KHLKFICILI ACGLDLASVG AMIVLVTDIE TRFNVSHTQS
61: GWALTSYVIT FAGFIAFFGR VGDIVGNGIM MCVFSVIFGI FSLLCAVVPN FIAFTVFRAF
121: QGMAGAGIVP CAYALVNKMF QGPNLQRYFS ILSSVISAMA GVGFIIGGAF GETALGYKSF
181: FYFLFAASLA TAAVICVLIG YPELLLNRHS YKEKFQRVYK LDVIGCLLFI SGSILLVVGL
241: TQGGESWNDP TAYVPLAVSI VLLIIFFMWN LGYAVVLKLI KPISTHKGYA YMESVNLLIP
301: KNLMFSHNFI PVLLATFFLF CGFMVVMYVI ANYSATVEGN SMIVASIKII PMISGLVLAN
361: GTVAYKQDLF KPKNALVVGS FISILGGAFF VPIKYVDDNL FWKLFFMGGF FTGLGGAFFF
421: CYMITMAIGD APDQYKALAG GIVQTSGQFG NEVSLSIVIS LLGNQTTDKA DLRDRFQNAS
481: YIVITAATIS TLVSLFLVKG PLESSGDEEK QLSECSESTT SSNSNPENQI ETVMVICPDT
541: RDKKEETVDQ YLA