2.A.1.3.79
Multidrug resistance MFS exporter, MFS54 of 538 aas and 14 TMSs. A fungal mutant lacking AaMFS54 produced fewer conidia and showed increased sensitivity to many potent oxidants (potassium superoxide and singlet-oxygen generating compounds) as well as xenobiotics (2,3,5-triiodobenzoic acid and 2-chloro-5-hydroxypyridine), and fungicides (clotrimazole, fludioxonil, vinclozolin, and iprodione) (Lin et al. 2018). Virulence assays on citrus leaves inoculated by spraying with spores revealed that AaMFS54 mutant induced less severe lesions than wild-type.
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| Accession Number: | OWY53006.1 |
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| Protein Name: | OWY53006.1 MFS general substrate transporter [Alternaria alternata] |
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| Length: | 539 |
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| Molecular Weight: | |
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| Species: | Alternaria alternata [5599] |
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| Number of TMSs: | 14 |
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| Substrate |
xenobiotic |
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1: MKEGVVTPPD SEKDLQNVEG SLNTEEEKAE EAHIQLSKGR FVLVLVGLVL AIFLASLDFT
61: IISTAIPKIT DEFHSLQDIG WYGSAFFITT AATTAHWGRL YTFFPLKWTY LTSIFFFELG
121: SVICGAAPSS TALIIGRAIC GIGAAGLFSG SYTIIAVLVP SADRPKYSGL MGASYGLASV
181: VGPLIGGAFT SHVSWRWCFY INLPVGGVSC LFILLFFANE PPKSRPDWRG MLRQLDMLGL
241: VLIVGAITCF ILALQWGGVS KAWDSGAVIG TLVAFVVCMI LFVIEQWWLG ENAMVHSVMI
301: KRRTIWVGSM FSFLINSAFL VTFYYLPIYF QSVQGVSAST SGVRTVPFIL AVTFCVVIVG
361: QIITKTGYAF PWMIVGAAIT TIGSGMIYTF DTHSPAGKWI GYQILCGIGV GVSFQVPVML
421: IQATTKDADV PLATATLLFI QTLGGAFGVS SAQAAFQNTL LKQLAITAPG LNPQIVLDAG
481: ASELKRVIPE QFLQGVLEAY VSGFRECLIV GIAFGGAAFL AAFGFRFTNI KRTAAAEA