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2.A.1.32.3
Putative copper/multidrug efflux protein, YfmO.  The yfmPO operon is autoregulated by the MerR homologue, YfmP (a repressor). The copZA operon encodes CopA, a copper ATPase (TC# 3.A.3.5.18) which is induced by a copper dependent mechanism. Since a yfmP null mutant had poor copZA induction but elevated levels of the YfmO efflux pump, YfmO could catalyze copper efflux and be responsible for reduced copZA induction. Consistent with this model, a yfmP yfmO double mutant showed normal induction by copper (Gaballa et al. 2003).

Accession Number:O06473
Protein Name:Multidrug efflux protein yfmO
Length:396
Molecular Weight:41451.00
Species:Bacillus subtilis (strain 168) [224308]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate copper(2+), drug

Cross database links:

Entrez Gene ID: 936111   
Pfam: PF07690   
KEGG: bsu:BSU07400   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006825 P:copper ion transport
GO:0055085 P:transmembrane transport

References (3)

[1] “A 23.4 kb segment at the 69 degrees-70 degrees region of the Bacillus subtilis genome.”  Yamamoto H.et.al.   9141694
[2] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[3] “Two MerR homologues that affect copper induction of the Bacillus subtilis copZA operon.”  Gaballa A.et.al.   14663075

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MDKTTQVNQK TGLLSQPKAV WAVAFACVIS FMGIGLVDPI LPAIAAQLHA SPSEVSLLFT 
61:	SYLLVTGFMM FFSGAISSRI GAKWTLILGL IFIIVFAGLG GSSSSIAQLV GYRGGWGLGN 
121:	ALFISTALAV IVGVSVGGSA QAIILYEAAL GLGISVGPLA GGELGSISWR APFFGVSVLM 
181:	FIALIAISFM LPKLPKPAKR VGVFDAMKAL KYKGLLTMAV SAFLYNFGFF ILLAYSPFVL 
241:	DLDEHGLGYV FFGWGLLLAI TSVFTAPLVH KALGTVRSLV VLFIAFAAIL VIMGIWTDHQ 
301:	TLIITCIVVA GAVLGMVNTI MTTAVMGSAP VERSIASSAY SSVRFIGGAL APWIAGMLSE 
361:	HFTASTPYTV GGIVVFVGML VLLMGRKHLA GIKAGH