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2.A.1.4.3 Glycerol-P:P_i antiporter (may function by a 'rocker switch' mechanism; Law et al., 2007). The 3-d structure is known (3.3Å resolution) (Huang et al., 2003; Lemieux et al., 2005; Lemieux, 2007).
Accession Number:	P08194
Protein Name:	GlpT aka B2240
Length:	452
Molecular Weight:	50310.00
Species:	Escherichia coli [83333]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	glycerol 1-phosphate

Structure:
RefSeq:	AP_002837.1 NP_416743.1
Entrez Gene ID:	946704
Pfam:	PF07690
BioCyc:	EcoCyc:GLPT-MONOMER ECOL168927:B2240-MONOMER
KEGG:	ecj:JW2234 eco:b2240
Gene Ontology GO:0016021 C:integral to membrane GO:0015527 F:glycerol-phosphate:inorganic phosphate anti... GO:0006071 P:glycerol metabolic process GO:0015794 P:glycerol-3-phosphate transport GO:0055085 P:transmembrane transport
References (7) [1] “Nucleotide sequence and transcriptional startpoint of the glpT gene of Escherichia coli: extensive sequence homology of the glycerol-3-phosphate transport protein with components of the hexose-6-phosphate transport system.” Eiglmeier K.et.al. 3329281 [2] “Construction of a contiguous 874-kb sequence of the Escherichia coli-K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features.” Yamamoto Y.et.al. 9205837 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “The transmembrane topology of the sn-glycerol-3-phosphate permease of Escherichia coli analysed by phoA and lacZ protein fusions.” Goett P.et.al. 3141744 [6] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996 [7] “Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli.” Huang Y.et.al. 12893936
1PW4

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MLSIFKPAPH KARLPAAEID PTYRRLRWQI FLGIFFGYAA YYLVRKNFAL AMPYLVEQGF 
61:	SRGDLGFALS GISIAYGFSK FIMGSVSDRS NPRVFLPAGL ILAAAVMLFM GFVPWATSSI 
121:	AVMFVLLFLC GWFQGMGWPP CGRTMVHWWS QKERGGIVSV WNCAHNVGGG IPPLLFLLGM 
181:	AWFNDWHAAL YMPAFCAILV ALFAFAMMRD TPQSCGLPPI EEYKNDYPDD YNEKAEQELT 
241:	AKQIFMQYVL PNKLLWYIAI ANVFVYLLRY GILDWSPTYL KEVKHFALDK SSWAYFLYEY 
301:	AGIPGTLLCG WMSDKVFRGN RGATGVFFMT LVTIATIVYW MNPAGNPTVD MICMIVIGFL 
361:	IYGPVMLIGL HALELAPKKA AGTAAGFTGL FGYLGGSVAA SAIVGYTVDF FGWDGGFMVM 
421:	IGGSILAVIL LIVVMIGEKR RHEQLLQERN GG

2.A.1.4.3
Glycerol-P:P_i antiporter (may function by a 'rocker switch' mechanism; Law et al., 2007). The 3-d structure is known (3.3Å resolution) (Huang et al., 2003; Lemieux et al., 2005; Lemieux, 2007).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

2.A.1.4.3Glycerol-P:Pi antiporter (may function by a 'rocker switch' mechanism; Law et al., 2007). The 3-d structure is known (3.3Å resolution) (Huang et al., 2003; Lemieux et al., 2005; Lemieux, 2007).

Cross database links:

Gene Ontology

References (7)

External Searches:

Analyze:

2.A.1.4.3
Glycerol-P:P_i antiporter (may function by a 'rocker switch' mechanism; Law et al., 2007). The 3-d structure is known (3.3Å resolution) (Huang et al., 2003; Lemieux et al., 2005; Lemieux, 2007).