2.A.1.40.2 Major facilitator superfamily domain-containing protein 5, MFSD5 or SLC61A1, of 450 aas and 13 TMSs in a 5 + 2 + 6 TMS arrangement. It mediates high-affinity (550 nM Km) intracellular uptake of the rare oligo-element molybdenum. It is probably a molybdate (the oxianion molybdate)/anion uptake porter (Tejada-Jiménez et al. 2011). In mammals, it is expressed in the brain and may play a role in energy homeostasis (Perland et al. 2016).
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Accession Number: | Q6N075 |
Protein Name: | Molybdate-anion transporter |
Length: | 450 |
Molecular Weight: | 49765.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 13 |
Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
Substrate |
molybdate |
---|
1: MLVTAYLAFV GLLASCLGLE LSRCRAKPPG RACSNPSFLR FQLDFYQVYF LALAADWLQA
61: PYLYKLYQHY YFLEGQIAIL YVCGLASTVL FGLVASSLVD WLGRKNSCVL FSLTYSLCCL
121: TKLSQDYFVL LVGRALGGLS TALLFSAFEA WYIHEHVERH DFPAEWIPAT FARAAFWNHV
181: LAVVAGVAAE AVASWIGLGP VAPFVAAIPL LALAGALALR NWGENYDRQR AFSRTCAGGL
241: RCLLSDRRVL LLGTIQALFE SVIFIFVFLW TPVLDPHGAP LGIIFSSFMA ASLLGSSLYR
301: IATSKRYHLQ PMHLLSLAVL IVVFSLFMLT FSTSPGQESP VESFIAFLLI ELACGLYFPS
361: MSFLRRKVIP ETEQAGVLNW FRVPLHSLAC LGLLVLHDSD RKTGTRNMFS ICSAVMVMAL
421: LAVVGLFTVV RHDAELRVPS PTEEPYAPEL