2.A.1.49.4
Protein Spinster homologue 2 (Spns2 or protein two of hearts). Exports sphingosine-1-P (S1P) and the immunomodulating agent, FTY720 (Hisano et al. 2011; Nijnik et al. 2012). S1P is a secreted lipid mediator that functions in vascular development. In the yolk syncytial layer, Spns2 functions in S1P secretion,
thereby regulating myocardial precursor migration (Kawahara et al. 2009).
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| Accession Number: | A2SWM2 |
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| Protein Name: | Protein spinster homolog 2 |
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| Length: | 504 |
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| Molecular Weight: | 54670.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
fingolimod hydrochloride, sphingosine 1-phosphate |
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| Entrez Gene ID: |
568117
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| Pfam: |
PF07690
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| KEGG: |
dre:568117
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[1] “The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish.” Osborne N. et.al. 19062281
[2] “The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors.” Kawahara A. et.al. 19074308
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1: MCVESDGCEI EGCSSSDEVH TLSGSMSPAL KSRDLHHCRP GQKFHAALLR CRTPLVAAGI
61: LSFGNVLNYM DRYTVAGVLL DIQKQFKVGD SSAGLLQTVF ICSFMVAAPI FGYLGDRFNR
121: KIILSCGIFF WSAVTLLSSF ITKEYYWLLV LSRCLVGIGE SSYSSISPTI IGDLFTNNKR
181: TVMLSVFYLA IPLGSGLGYI LGSIAKDAGG HWYWALRVSP MLGLTAGTLI LIFVSEPKRG
241: SADQPGGRLK TRTSWVCDMK ALAKNRSYVF SSLASAAVSF ATGAFGIWIP QYLVRAQVVQ
301: KSAESCTYQP CSSRDSLIFG AITCVTGLLG VVIGAVTTRL CRQKTERADP LVCAVSMLGS
361: AIFICLIFVV AKKSIVGAYI CIFIGETLLF LNWAITADIL MYVVIPTRRA TAVAFQGFTS
421: HLLGDAGSPY LIGLISDSLQ ESYATSEIWQ FLSLGYALML CPFVIVLGGM FFLATALFFL
481: DDRDKAAKQV NQLARPPSTV KVTK