2.A.1.49.6
Sphingosine-1-phosphate/dehydrosphingosine-1-P transport protein, Spinster 2, SPNS2 of 549 aas and 12 TMSs. It is involved in immune development and lymphocyte trafficing (Nijnik et al. 2012; Fukuhara et al. 2012). The functions and the mechanisms of SPNS2 in the pathogenesis of cancer have been reviewed (Fang et al. 2020).
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| Accession Number: | Q8IVW8 |
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| Protein Name: | Protein spinster homolog 2 |
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| Length: | 549 |
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| Molecular Weight: | 58044.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sphingosine 1-phosphate |
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| Entrez Gene ID: |
124976
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| Pfam: |
PF07690
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| KEGG: |
hsa:124976
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[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
[2] “The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors.” Kawahara A. et.al. 19074308
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1: MMCLECASAA AGGAEEEEAD AERRRRRRGA QRGAGGSGCC GARGAGGAGV SAAGDEVQTL
61: SGSVRRAPTG PPGTPGTPGC AATAKGPGAQ QPKPASLGRG RGAAAAILSL GNVLNYLDRY
121: TVAGVLLDIQ QHFGVKDRGA GLLQSVFICS FMVAAPIFGY LGDRFNRKVI LSCGIFFWSA
181: VTFSSSFIPQ QYFWLLVLSR GLVGIGEASY STIAPTIIGD LFTKNTRTLM LSVFYFAIPL
241: GSGLGYITGS SVKQAAGDWH WALRVSPVLG MITGTLILIL VPATKRGHAD QLGDQLKART
301: SWLRDMKALI RNRSYVFSSL ATSAVSFATG ALGMWIPLYL HRAQVVQKTA ETCNSPPCGA
361: KDSLIFGAIT CFTGFLGVVT GAGATRWCRL KTQRADPLVC AVGMLGSAIF ICLIFVAAKS
421: SIVGAYICIF VGETLLFSNW AITADILMYV VIPTRRATAV ALQSFTSHLL GDAGSPYLIG
481: FISDLIRQST KDSPLWEFLS LGYALMLCPF VVVLGGMFFL ATALFFVSDR ARAEQQVNQL
541: AMPPASVKV