2.A.1.53.6
MFS uptake permease specific for pyrimidines, PhtC of 422 aas and 12 TMSs. Together with PhtD (TC# 2.A.1.53.6), it contributes to protection of L. pneumophila from dTMP starvation, protects the cell from 5-fluorodeoxyuridine (FUdR) toxicity and is required for growth of L. pneumophila in macrophage (Fonseca et al. 2014).
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| Accession Number: | I7I0I1 |
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| Protein Name: | Major facilitator family transporter |
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| Length: | 422 |
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| Molecular Weight: | 46477.00 |
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| Species: | Legionella pneumophila subsp. pneumophila [91891] |
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| Number of TMSs: | 12 |
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| Substrate |
pyrimidine |
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1: MSHSVAVESK TFVPRGDFMA WVVCLSAGLF FLYEFFQLNI FDVINQSLRE DFHIDATQLS
61: WMSSTYLWAD ILFLLPAGLI LDRFSTRKVI LTAMFVCVVG TIGFAVTESF FLASFFHFLS
121: GIGNAFCFLS CVVLVSHWFP PRRQALVIGS LVTMAFIGGM MAHTPFAYLN DLFGWRRALL
181: IDGVVGAFLI LWIYMIVQDR PEESPAHKLT NEGQILSSFM KALSNKQNWL AGLYTSLLNL
241: PIMVLCALWG ASYLQVAHHL PDIAASNVVS LIFMGSVVGC PLVGWLSDTQ GRRKPLMIFG
301: AIATLITTIP LFINVVLTQM SLSILFFALG LFTSTQVISY PLVAESNQPE NTGAATGIAS
361: VIIMGGGGVA QVLFGWLMTH HAGTNVTAYT VSDFQFAMWM FPVAAIAGLV AVLMTRETYC
421: KR