2.A.1.62.5
Putative MFS efflux pump of 389 aas and 12 TMSs. Expression of the gene encoding this transporter is governed by a quorum sensing (QS) system, and it impacts the expression of multiple virulence factors, accounting for QS-dependent antibiotic susceptibility (Chang et al. 2022).
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| Accession Number: | ACI60791.1 |
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| Protein Name: | ACI60791.1 Putative efflux protein [Streptococcus pyogenes NZ131] |
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| Length: | 390 |
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| Molecular Weight: | |
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| Species: | Streptococcus pyogenes NZ131 [471876] |
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| Number of TMSs: | 12 |
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| Substrate |
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1: MNNRKKNIQY LVYSKVIYRI GDVMFDFANN TFLAGLNPAS LSLVAVYQSL ESVIGVLFNL
61: FGGVIADSFK RKKIIITTNI LCGTACLVLS FLTKEQWLVY AIVLTNVILA FMSAFSSPSY
121: KAFTKEIVKK DSISQLNSLL ETTSTVIKVT VPMVAIFLYK LLGIHGVLLL DGLSFLIAAL
181: LISFILPVND EVVIKEKVTI REIFNDLKIG FKYVYSHKSI FIITVLSALV NFFLAAYNLL
241: LPYSNQMFGE ISTGLYGTFL TAEAIGGFIG AILSGFVNKE LSSMRLILFL SLSGLMLMLA
301: PPFYIMFHNA IILALSPALF SLFLSIFNIQ FFSLVQKDVD NDFLGRVFGI IFTITILFMP
361: IGTGFFSVGL NPNNSFNLLL LVRALLYCH