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2.A.1.65.6 Macrophage MHC Class I receptor 2, Mmr2 or MFSD6. The ortholog of this protein in humans is a also called MFSD6 and is 90% identical to the mouse protein (Bagchi et al. 2020). This disease protein shows increased expression levels with increased energy consumption (Bagchi et al. 2020).
Accession Number:	Q8CBH5
Protein Name:	Major facilitator superfamily domain-containing protein 6
Length:	775
Molecular Weight:	86076.00
Species:	Mus musculus (Mouse) [10090]
Number of TMSs:	12
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate

Entrez Gene ID:	98682
Pfam:	PF07690
KEGG:	mmu:98682 mmu:98682
Gene Ontology GO:0016021 C:integral to membrane GO:0004872 F:receptor activity GO:0055085 P:transmembrane transport
References (8) [1] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [2] “Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice.” Tashiro-Yamaji J.et.al. 17010536 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “The phagosomal proteome in interferon-gamma-activated macrophages.” Trost M.et.al. 19144319 [5] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [6] “Macrophage MHC receptor 2: a novel receptor on allograft (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC class I molecule, H-2K(d), in mice.” Tashiro-Yamaji J.et.al. 17010536 [7] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [8] “The phagosomal proteome in interferon-gamma-activated macrophages.” Trost M.et.al. 19144319

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MAADDKVAIL TDDEEEQKRK YVLADPFNGI CREPEPPSNE TPSSTETSAI PEEEIDWIEK 
61:	HCVKVNNDLL ISKVFYFFFY SAYGSLYPLL PVYYKQLGMS PSQSGLLVGI RYFIEFCSAP 
121:	FWGVVADRFR KGKIVLLFSL LCWVLFNLGI GFVKPATLRC LPKIPPTAHP TNVSHPVTVL 
181:	PMNSSTVAFF STPPKLLQKR DVQLSETEPN ISDIDLVSTA LTLTSEPTRR PQTEAITHPV 
241:	TGLILNTSTV TLPPTGNVTR ETTIAVVTTT KSLPSDQVTL VYDQQEVEAI FLIILVVVII 
301:	GEFFSASSVT IVDTVTLQYL GKHRDRYGLQ RMWGSLGWGL AMLSVGIGID YTHIDVLIDG 
361:	KGCKPPEYRN YQIVFIVFGV LMTMALIVAT QFRFRYNHFN NSDGKGKEVE IPQVERDNST 
421:	ESSEETPTAA THSQAFNFWD LIKLLCSVQY GSVLFVAWFM GFGYGFVFTF LYWHLEDLNG 
481:	TTTLFGVCSV LSHVSELTAY FFSHKLIELI GHIRVLYIGL ACNTARYIYI SYLENAWTVL 
541:	PMEVLQGVTH AAIWAACISY LSAAVPPELR TSAQGILQGL HLGLGRGCGA MIGGVLVNYF 
601:	GAAATFRGIG MACLVILLLF ALIQWLAVPD EEEDKTMLAE RIPVPSSPVP IATIDLVQQQ 
661:	TEDVMPRVEA RLPPKKTKHQ EEQEDVNKPA WGVSSSPWVT FVYALYQVKE LIQLTRESRA 
721:	SEIQPLQVTL CWASVASAPL LPPCSSKHMG NRKTGMLAKD ISGLRSLCHS VYQVA

2.A.1.65.6
Macrophage MHC Class I receptor 2, Mmr2 or MFSD6. The ortholog of this protein in humans is a also called MFSD6 and is 90% identical to the mouse protein (Bagchi et al. 2020). This disease protein shows increased expression levels with increased energy consumption (Bagchi et al. 2020).

Cross database links:

Gene Ontology

References (8)

External Searches:

Analyze:

2.A.1.65.6Macrophage MHC Class I receptor 2, Mmr2 or MFSD6. The ortholog of this protein in humans is a also called MFSD6 and is 90% identical to the mouse protein (Bagchi et al. 2020). This disease protein shows increased expression levels with increased energy consumption (Bagchi et al. 2020).

Cross database links:

Gene Ontology

References (8)

External Searches:

Analyze:

2.A.1.65.6
Macrophage MHC Class I receptor 2, Mmr2 or MFSD6. The ortholog of this protein in humans is a also called MFSD6 and is 90% identical to the mouse protein (Bagchi et al. 2020). This disease protein shows increased expression levels with increased energy consumption (Bagchi et al. 2020).