2.A.1.7.24
MFS porter, MFSD4a or SLC60A1, of 514 aas and 12 TMSs. In the mouse, this protein and MFSD9 localize to neurons in the
brain, and their mRNA expression levels are affected by diet (Perland et al. 2017). They are associated with cancer and have anti-tumor activities (Yang et al. 2022). It may play a role in the excretion of nitrogen metabolites (Honerlagen et al. 2021).
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| Accession Number: | Q8N468 |
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| Protein Name: | Major facilitator superfamily domain-containing protein 4A |
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| Length: | 514 |
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| Molecular Weight: | 56265.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MGCDGRVSGL LRRNLQPTLT YWSVFFSFGL CIAFLGPTLL DLRCQTHSSL PQISWVFFSQ
61: QLCLLLGSAL GGVFKRTLAQ SLWALFTSSL AISLVFAVIP FCRDVKVLAS VMALAGLAMG
121: CIDTVANMQL VRMYQKDSAV FLQVLHFFVG FGALLSPLIA DPFLSEANCL PANSTANTTS
181: RGHLFHVSRV LGQHHVDAKP WSNQTFPGLT PKDGAGTRVS YAFWIMALIN LPVPMAVLML
241: LSKERLLTCC PQRRPLLLSA DELALETQPP EKEDASSLPP KFQSHLGHED LFSCCQRKNL
301: RGAPYSFFAI HITGALVLFM TDGLTGAYSA FVYSYAVEKP LSVGHKVAGY LPSLFWGFIT
361: LGRLLSIPIS SRMKPATMVF INVVGVVVTF LVLLIFSYNV VFLFVGTASL GLFLSSTFPS
421: MLAYTEDSLQ YKGCATTVLV TGAGVGEMVL QMLVGSIFQA QGSYSFLVCG VIFGCLAFTF
481: YILLLFFHRM HPGLPSVPTQ DRSIGMENSE CYQR