2.A.1.70.8 Uncharacterized MFS porter of 397 aas and 12 TMSs, annotated in Uniprot as ArsP. The encoding gene is next to genes encoding ArsH (Q1LRL2), an NADPH-dependent FMN reductase, ArsC1, an arsenate reductase (Q1LRL1) and an arsenite efflux pump, ArsB or Acr3 of 10 TMSs (ArsB; Q1LRL0; ACR family, TC# 2.A.59). This MFS family shows greatest similarity with families 2.A.1.11 and 2.A.1.13, both which transport anionic speices, for example, oxalate, formate and pyruvate (TC# 2.A.1.11) and monocarboxylates (TC# 2.A.1.13). It is 32% identical and 52% similar to ArsK (TC# 2.A.1.70.9) which is an arsenite/antimonite exporter (Shi et al. 2018).
|
Accession Number: | Q1LRL3 |
Protein Name: | Permease of the Major Facilitator Family |
Length: | 397 |
Molecular Weight: | 40512.00 |
Species: | Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34) [266264] |
Number of TMSs: | 12 |
Substrate |
|
---|
1: MEPSSSVIAR LGVAQTLAWG STYYLPAMLA TPMAQDLGVS TPTIFAAFSV ALVVSALLGP
61: AAGRMIDRTG GRSVLVATSL VFTIGLARLG VAQGVVGLFA AWVILGIGMG AGLYEAAFAT
121: LVALYGNRSR GAITGITLIA GFASTVGWPL STSMEAHIGW RGACLSWAAL HLTLGLALNL
181: SIPRVAATAT APSRPTSQTG SALTHHADER SQRTASYALA FVFAATWFIS TAMAAHLPRL
241: LQAGGASLAT AVMVGALIGP AQVGARILEF GLLRKVHPLL SARIAAALHP LGALAFGLVG
301: APAAALFGVL HGAGNGILTI AKGTLPLVIF GPGGYGHRQG VLMVPARVAQ ALAPWIFGMC
361: LDQFGAKSLW LSSALGMMAI LTLMAVRQSA PLKTSTT