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2.A.1.8.12
The root cortical and epidermal cell, high affinity, plasma membrane, NO3- uptake transporter, NRT2.1 (Wirth et al., 2007). Also functions in nitrate sensing and signaling (Miller et al., 2007; Girin et al., 2010). Activity only occurs when NRT2.1 is complexed with NAR2.1 (WR3; 8.A.20.1.1) in a 2:2 tetrameric complex (Yong et al., 2010). NAR2.1 has an N-terminal and a C-terminal TMS and has been annotated as a calcineurin-like phosphoesterase family member (Yong et al., 2010).  Ntr transporters may also play a role in gaseous NO2 uptake by leaves (Hu et al. 2014).  The Medicago truncatula orthologue has been characterized (Pellizzaro et al. 2014). An NRT2 homologue in wheat has been identifed and partially characterized (Kumar et al. 2022).

Accession Number:O82811
Protein Name:High-affinity nitrate transporter ACH1 aka NRT2.1
Length:530
Molecular Weight:57710.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate anion, nitrate

Cross database links:

RefSeq: NP_172288.1   
Entrez Gene ID: 837327   
Pfam: PF07690   
KEGG: ath:AT1G08090   

Gene Ontology

GO:0015112 F:nitrate transmembrane transporter activity
GO:0048527 P:lateral root development
GO:0015706 P:nitrate transport
GO:0010167 P:response to nitrate
GO:0055085 P:transmembrane transport

References (3)

[1] “Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.”  Theologis A.et.al.   11130712
[2] “Nitrate transport: a key step in nitrate assimilation.”  Daniel-Vedele F.et.al.   10066586
[3] “Expression analysis of a high-affinity nitrate transporter isolated from Arabidopsis thaliana by differential display.”  Filleur S.et.al.   9951738

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGDSTGEPGS SMHGVTGREQ SFAFSVQSPI VHTDKTAKFD LPVDTEHKAT VFKLFSFAKP 
61:	HMRTFHLSWI SFSTCFVSTF AAAPLVPIIR ENLNLTKQDI GNAGVASVSG SIFSRLVMGA 
121:	VCDLLGPRYG CAFLVMLSAP TVFSMSFVSD AAGFITVRFM IGFCLATFVS CQYWMSTMFN 
181:	SQIIGLVNGT AAGWGNMGGG ITQLLMPIVY EIIRRCGSTA FTAWRIAFFV PGWLHIIMGI 
241:	LVLNLGQDLP DGNRATLEKA GEVAKDKFGK ILWYAVTNYR TWIFVLLYGY SMGVELSTDN 
301:	VIAEYFFDRF HLKLHTAGLI AACFGMANFF ARPAGGYASD FAAKYFGMRG RLWTLWIIQT 
361:	AGGLFCVWLG RANTLVTAVV AMVLFSMGAQ AACGATFAIV PFVSRRALGI ISGLTGAGGN 
421:	FGSGLTQLLF FSTSHFTTEQ GLTWMGVMIV ACTLPVTLVH FPQWGSMFLP PSTDPVKGTE 
481:	AHYYGSEWNE QEKQKNMHQG SLRFAENAKS EGGRRVRSAA TPPENTPNNV