2.A.1.81.1
The copper (Cu²⁺) uptake porter, CcoA of 405 aas and 12 TMSs. CcoA-mediated Cu²⁺ import relies on conserved Met and His residues that could act as metal ligands at the membrane-embedded Cu²⁺-binding domain (Khalfaoui-Hassani et al. 2016). It provides cytoplasmic Cu needed for cbb3-type cytochrome c oxidase (cbb3-Cox) biogenesis (Khalfaoui-Hassani et al. 2021). Residues important for and/or esstential for function have been identified. CcoA undergoes a thiol:disulfide oxidoreduction cycle, which is important for its Cu import activity (Khalfaoui-Hassani et al. 2021).