2.A.1.82.6
Synaptic vesicle 2-related protein, SVOPL, of 492 aas and 12 TMSs in a 6 + 1 + 5 TMS arrangement. Gene disruption gives rise to neurocognitive disabilities (Nilsson et al. 2017), and mutations can give rise to retinal dystrophies, hereditary blinding disorders (Patel et al. 2018). SVOPL is also a potential cell survival gene that undergoes allelic switching (Boot et al. 2019).
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| Accession Number: | Q8N434 |
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| Protein Name: | Putative transporter SVOPL |
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| Length: | 492 |
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| Molecular Weight: | 53991.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MATKPTEPVT ILSLRKLSLG TAEPQVKEPK TFTVEDAVET IGFGRFHIAL FLIMGSTGVV
61: EAMEIMLIAV VSPVIRCEWQ LENWQVALVT TMVFFGYMVF SILFGLLADR YGRWKILLIS
121: FLWGAYFSLL TSFAPSYIWF VFLRTMVGCG VSGHSQGLII KTEFLPTKYR GYMLPLSQVF
181: WLAGSLLIIG LASVIIPTIG WRWLIRVASI PGIILIVAFK FIPESARFNV STGNTRAALA
241: TLERVAKMNR SVMPEGKLVE PVLEKRGRFA DLLDAKYLRT TLQIWVIWLG ISFAYYGVIL
301: ASAELLERDL VCGSKSDSAV VVTGGDSGES QSPCYCHMFA PSDYRTMIIS TIGEIALNPL
361: NILGINFLGR RLSLSITMGC TALFFLLLNI CTSSAGLIGF LFMLRALVAA NFNTVYIYTA
421: EVYPTTMRAL GMGTSGSLCR IGAMVAPFIS QVLMSASILG ALCLFSSVCV VCAISAFTLP
481: IETKGRALQQ IK