TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.105.1.1









Mitochondrial pyruvate carrier, MPC1/2/3 (MPC1: 130 aas and probably 3 TMSs; MPC2: 129 aas and 3 TMSs; MPC3: 146 aas and 3 TMSs) (Bricker et al., 2012; Herzig et al., 2012). Yeast MPC proteins with 3 TMSs and a matrix-exposed N-terminus are imported by the carrier pathway, using the receptor Tom70, small TIM chaperones, and the TIM22 complex (Rampelt et al. 2020). The TIM9.10 complex chaperones MPC proteins through the mitochondrial intermembrane space using conserved hydrophobic motifs that are also required for the interaction with canonical carrier proteins. Thus, the carrier pathway can import paired and non-paired TMSs and translocate N-termini to either side of the mitochondrial inner membrane, revealing an unexpected versatility of the mitochondrial import pathway for non-cleavable inner membrane proteins (Rampelt et al. 2020). MPC transporters have been reviewed (Cunningham and Rutter 2020).

Eukaryota
Fungi, Ascomycota
MPC1/2/3 of Saccharomyces cerevisiae
MPC1 (P53157)
MPC2 (P38857)
MPC3 (P53311) 
2.A.105.1.2









Mitochondrial pyruvate carrier, MPC1/2, SLC4A1/SLC4A2 (Gyimesi and Hediger 2022): (MPC1: 109aas; 2-3 TMSs; MPC2: 127aas; 3 TMSs) (Bricker et al., 2012; Herzig et al., 2012). Aceylation of lys19 and lys26 in MPC2 decreases activity of this transporter. Deficient pyruvate transport activity, mediated in part by acetylation of MPC2, is a contributor to metabolic inflexibility in the diabetic heart (Vadvalkar et al. 2017). Both subunits  (MPC1 and 2) contain three TMSs with substantial differences from what was predicted by AlphaFold2 (Li et al. 2022).

Eukaryota
Metazoa, Chordata
MPC1/2 of Homo sapiens 
MPC1 (Q9Y5U8)
MPC2 (O95563) 
2.A.105.1.3









Mitochondrial pyruvate carrier (MPC1/2) (MPC1: 107aas; 3 TMSs; MPC2: 154aas; 3 TMSs) (Bricker et al., 2012).

Eukaryota
Metazoa, Arthropoda
MPC1/2 of Drosophila melanogaster 
MPC1 (Q7KSC4)
MPC2 (Q9VHB1) 
2.A.105.1.4









MPC1/2 (MPC1: 146aas; 4 TMSs; MPC2: 108aas; 3 TMSs; MPC3?: 110aas; 2-3 TMSs)

Eukaryota
Viridiplantae, Streptophyta
MPC1/2 of Arabidopsis thaliana 
MPC1 (Q84VZ9)
MPC2 (Q8L7H8)
MPC3? (Q949R9) 
2.A.105.1.5









MPC (117aas; 3 TMSs)

Eukaryota
Ciliophora
MPC of Paramecium tetraurelia (A0CVJ5)
2.A.105.1.6









MPC (97aas; 3 TMSs)

Eukaryota
Apicomplexa
MPC of Theileria parva (Q4N4U8)
2.A.105.1.7









MPC (140aas; 3 TMSs)

Eukaryota
Euglenozoa
MPC of Leishmania braziliensis (A4H7W6)
2.A.105.1.8









MPC homologue of 267 aas and 5 - 8 TMSs.

Eukaryota
Perkinsozoa
MPC homologue of Perkinsus marinus
2.A.105.1.9









MPC homologue of 349 aas and 8 putative TMSs

Eukaryota
Perkinsozoa
MPC homologue of Perkinsus marinus
2.A.105.1.10









MPC homologue of 268 aas and 6 - 8 TMSs.

Eukaryota
MPC homologue of Aureococcus anophagefferens (Harmful bloom alga)
2.A.105.1.11









MPC homologue of 319 aas and 6 - 8 TMSs.

Eukaryota
Oomycota
MPC homologue of Phytophthora sojae (Soybean stem and root rot agent) (Phytophthora megasperma)
2.A.105.1.12









MPC homologue of 189 aas and 3 - 4 TMSs.

Eukaryota
Fungi, Ascomycota
MPC homologue of Uncinocarpus reesii
2.A.105.1.13









Mitochondrial pyruvate carrier 1-like, MPC1L (SLC54A3) of 1136 aas and probably 3 TMSs.

Eukaryota
Metazoa, Chordata
MPC1L of Homo sapiens
2.A.105.1.14









Mitochondrial pyruvate carrier, MPC, of 106 aas and 3 TMSs.

Eukaryota
Apicomplexa
MPC of Plasmodium falciparum
2.A.105.1.15









Mitochondrial pyruvate carrier, MPC2, of 129 aas and 3 TMSs

Eukaryota
Apicomplexa
MPC2 of Plasmodium falciparum