2.A.110.2.1 The LHR1 heme uptake transporter (Huynh et al. 2012). In Leishmania amazonensis, LHR1 is essential for virulence (Miguel et al. 2013). Transport depends on tyrosyl residues in the first three TMSs of the protein (Renberg et al. 2015).
|
Accession Number: | E9BH93 |
Protein Name: | Hypothetical predicted multi-pass transmembrane protein |
Length: | 175 |
Molecular Weight: | 19984.00 |
Species: | Leishmania donovani (strain BPK282A1) [981087] |
Number of TMSs: | 4 |
Substrate |
ferroheme b |
---|
1: MNELERKRRT FRIWLAIYII FALAYLSGVL LFCFVHQNYW ACGGFVVVIL LIALRVALLA
61: TPQYRLYKIF PPCSFSRIAY QTFFLCACLV GISLGVWLMA RGIKHRQSWT ARSYFCGMTG
121: MWMAAKWSYI VTVPIYDLRE DTLEEDALIR LGLIDSGKDK ASGSNEPVTL KANCA