TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.121.1.1









Sulfate transporter, CysZ.  Part of the cysteine biosynthetic pathway; allosterically inhibited by the biosynthetic intermediate, sulfite (Zhang et al. 2014).

Bacteria
Pseudomonadota
CysZ of E. coli (POA6J3)
2.A.121.1.2









CysZ homologue

Bacteria
Actinomycetota
CysZ homologue of Streptomyces coelicolor
2.A.121.1.3









Uncharacterized protein, CysZ homologue.

Bacteria
Pseudomonadota
CysZ homologue of Idiomarina loihiensis
2.A.121.1.4









Sulfate uptake porter of 246 aas and 4 or 5 TMSs.  CysZ from Pseudomonas denitrificans assembles as a trimer of antiparallel dimers, and the CysZ structures from two other species recapitulate dimers from this assembly. Mutational studies highlighted the functional relevance of conserved CysZ residues (Assur Sanghai et al. 2018).

Bacteria
Pseudomonadota
CysZ of Pseudomonas denitrificans
2.A.121.2.1









Putative sulfate uptake transporter of 5 TMSs, YAL018c

Eukaryota
Fungi, Ascomycota
YAL018c of Saccharomyces cerevisiae (P31379)
2.A.121.2.2









The Rrt8p protein of 342 aas.

Eukaryota
Fungi, Ascomycota
Rrt8p of Saccharomyces cerevisiae (Q08219)
2.A.121.2.3









Uncharacterized protein of 429 aas and 5 TMSs.

Eukaryota
Fungi, Ascomycota
UP of Aspergillus niger (E2PST1)
2.A.121.2.4









CysZ homologue

Eukaryota
Fungi, Ascomycota
CysZ homologue of Fusarium oxysporum
2.A.121.2.5









The YOL047C protein

Eukaryota
Fungi, Ascomycota
YOL047C of Saccharomyces cerevisiae (Q08218)
2.A.121.2.6









Putative sulfate uptake porter of 288 aas and 4 or 5 TMSs.

Eukaryota
Fungi, Ascomycota
CysZ homologue of Neurospora crassa
2.A.121.2.7









Uncharacterized protein of 261 aas and 4 or 5 TMSs.

Eukaryota
Oomycota
UP of Phytophthora parasitica
2.A.121.2.8









Uncharacterized protein of 226 aas and 4 or 5 TMSs.

Eukaryota
Fungi, Ascomycota
UP of Ashbya gossypii (Yeast) (Eremothecium gossypii)
2.A.121.2.9









Uncharacterized protein of 309 aas and 5 TMSs

Eukaryota
Fungi, Ascomycota
UP of Pseudomassariella vexata
2.A.121.2.10









Uncharacterized protein of 367 aas and 4 or 5 TMSs

Eukaryota
Fungi, Basidiomycota
UP of Tremella mesenterica
2.A.121.2.11









Uncharacterized protein of 288 aas and 4 or 5 TMSs

Eukaryota
Fungi, Basidiomycota
UP of Phlebiopsis gigantea
2.A.121.2.12









Uncharacterized  protein of 282 aas and 5 TMSs.

Eukaryota
Fungi, Basidiomycota
UP of Neolentinus lepideus
2.A.121.2.13









Uncharacterized protein of 345 aas and 5or 6 TMSs.

Eukaryota
Fungi, Mucoromycota
UP of Mortierella verticillata
2.A.121.3.1









Etoposide-induced protein 2.4, isoform 1, Ei24, or p53-induced gene 8 protein, PIG8.  This protein is a apoptosis/autophagy factor (Rømer et al. 2008; Bahk et al. 2010).

Eukaryota
Metazoa, Chordata
Ei24 or Homo sapiens
2.A.121.3.2









Uncharacterized protein

Eukaryota
CysZ homologue of Monosiga brevicollis
2.A.121.3.3









Ei24 superfamily homologue

Eukaryota
Viridiplantae, Streptophyta
Ei24 homologue of Arabidopsis thaliana
2.A.121.4.1









The bacterial 4TMS CysZ homologue

Bacteria
Campylobacterota
CysZ homologue of Campylobacter coli (E0QD93)
2.A.121.4.2









5TMS Hypothetical protein, HP

Bacteria
Campylobacterota
HP of Helicobacter pylori (E6S4S3)
2.A.121.4.3









Unnamed protein

Bacteria
Pseudomonadota
Unnamed protein of Bartonella clarridgeiae (E6YFT5)
2.A.121.4.4









CysZ homologue

Bacteria
Pseudomonadota
CysZ homologue of Sideroxydans lithotrophicus
2.A.121.4.5









Uncharacterized protein of 298 aas and 7 TMSs

Bacteria
Campylobacterota
UP of Nautilia profundicola
2.A.121.4.6









Uncharacterized protein of 231 aas and 5 TMSs

Bacteria
Spirochaetota
UP of Leptospira interogans
2.A.121.4.7









Uncharacterized protein of 389 aas and 11 TMSs

Bacteria
Bacteroidota
UP of Bacteroides clarus
2.A.121.4.8









UP of 279 aas and 8 TMSs

Archaea
Candidatus Lokiarchaeota
UP of Lokiarchaeum sp. GC14_75