TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.126.1.1









Tmemb_14 family protein of 4 TMSs.  Show some sequence similarity with 2.A.7.26.3

Bacteria
Chlamydiae/Verrucomicrobia group
Tmemb_14 protein of Prarchlamydia acanthamoebae
2.A.126.1.2









Uncharacterized protein of 105 aas

Eukaryota
Longamoebia
UP of Acanthamoeba castellanii
2.A.126.1.3









Uncharacterized protein of 104 aas

Bacteria
Cyanobacteria
UP of Anabaena cylindrica
2.A.126.1.4









Uncharacterized protein of 102 aas

Eukaryota
Dictyosteliida
UP of Dictyostelium discoideum
2.A.126.1.5









Uncharacterized protein of 111 aas

Eukaryota
Metazoa
UP of Bombyx mori
2.A.126.1.6









Uncharacterized protein of 114 aas and 4 TMSs, TMEM14DP or TMEM14D.

Eukaryota
Metazoa
UP of Homo sapiens
2.A.126.1.7









Uncharacterized protein of 166 aas with 4 TMSs and an N-terminal hydrophilic extension

Eukaryota
Bangiophyceae
UP of Galdieria sulfuraria
2.A.126.1.8









Tmem_14 protein of 110 aas

Eukaryota
Fungi
UP of Candida albicans
2.A.126.1.9









Uncharacterized protein of 104 aas

Eukaryota
Fungi
UP of Chaetomium globosum
2.A.126.1.10









Uncharacterized protein of 116 aas

Eukaryota
Kinetoplastida
UP of Trypanosoma brucei
2.A.126.1.11









Uncharacterized protein of 105 aas and 4 TMSs

Eukaryota
Fungi
UP of Naumovozyma dairenensis (Saccharomyces dairenensis)
2.A.126.1.12









Uncharacterized protein of 116 aas

Bacteria
Planctomycetes
UP of Isophaera pallida
2.A.126.1.13









Uncharacterized protein of 105 aas and 4 TMSs

Eukaryota
Kinetoplastida
UP of Trypanosoma vivax
2.A.126.1.14









Putative MDR efflux pump of 153 aas and 4 TMSs

Eukaryota
Viridiplantae
Putative porter of Zea mays (Maize)
2.A.126.1.15









Uncharacterized protein of 125 aas and 4 TMSs

Bacteria
Cyanobacteria
UP of Nostoc punctiforme
2.A.126.1.16









Chloroplast fatty acid export 2 protein FAX2 of 240 aas and 4 TMSs.

Eukaryota
Viridiplantae
FAX2 of Arabidopsis thaliana
2.A.126.1.17









Uncharacterized protein of 129 aas

Eukaryota
Apicomplexa
UP of Babesia equi
2.A.126.1.18









Transmembrane Protein 14C (TMEM14C) of 112 aas and 4 TMSs. It is a mitochondrial porphyrin (protoporphyrinogen) transporter, essential for haem biosynthesis. It is an SF3B1 splicing target (Steensma et al. 2021).

Eukaryota
Opisthokonta
TMEM14C of Homo sapiens
2.A.126.1.19









TMEM14A of 99 aas and 4 TMSs. It inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in the apoptotic signaling pathway (). It inhibits N-(4-hydroxyphenyl)retinamide-induced apoptosis through the stabilization of the mitochondrial membrane potential (Woo et al. 2011).

Eukaryota
Opisthokonta
TMEM14A of Homo sapiens
2.A.126.1.20









TMEM14B of 114 aas and 4 TMSs.  It is a primate-specific protein involved in cortical expansion and folding in the developing neocortex. It may drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions (Liu et al. 2017).

Eukaryota
Opisthokonta
TMEM14B of Homo sapiens
2.A.126.2.1









Uncharacterized protein of 120 aas

Eukaryota
Viridiplantae
UP of Micromonas pusilla
2.A.126.2.2









Uncharacterized protein of 220 aas with 4 TMSs and an N-terminal hydrophilic extension

Eukaryota
Viridiplantae
UP of Capsella rubella
2.A.126.2.3









Uncharacterized protein of 120 aas and 4 TMSs

Eukaryota
Viridiplantae
UP of Chlorella variabilis (Green alga)
2.A.126.2.4









Plastid fatty acid export protein 1, FAX1, of 226 aas and 4 TMSs with an N-terminal hydrophlic domain (Li et al. 2015).

Eukaryota
Viridiplantae
FAX1 of Arabidopsis thaliana