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2.A.128.  The Multidrug Resistance Exporter VanZ (VanZ) Family

The antibiotic resistance gene vanZ has been identified, and expression of vanZ conferred resistance to teicoplanin and dalbavancin in Streptococcus agalactiae (Lai et al. 2017). The bacterial proton motive force (PMF) represents a target, providing a comprehensive approach to controlling antimicrobial resistance (Yang et al. 2023).

References associated with 2.A.128 family:

Lai, L., J. Dai, H. Tang, S. Zhang, C. Wu, W. Qiu, C. Lu, H. Yao, H. Fan, and Z. Wu. (2017). Streptococcus suis serotype 9 strain GZ0565 contains a type VII secretion system putative substrate EsxA that contributes to bacterial virulence and a vanZ-like gene that confers resistance to teicoplanin and dalbavancin in Streptococcus agalactiae. Vet Microbiol 205: 26-33. 28622857
Woods, E.C., D. Wetzel, M. Mukerjee, and S.M. McBride. (2018). Examination of the Clostridioides (Clostridium) difficile VanZ ortholog, CD1240. Anaerobe. [Epub: Ahead of Print] 29940245
Yang, B., Z. Tong, J. Shi, Z. Wang, and Y. Liu. (2023). Bacterial proton motive force as an unprecedented target to control antimicrobial resistance. Med Res Rev. [Epub: Ahead of Print] 36896761