TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
2.A.130.1.1









The Type 9 protein secretory system (T9SS) of about 15 components (Lauber et al. 2018).  See the family description for details, and the examples cited below for the characteristics and functions, when known, for the 15 potential constituents, which are listed with functional information in the left hand column of this entry (McBride and Zhu 2013). Veith et al. 2017 have reviewed theseLauber et al. 2018).  See the family description for details, and the examples cited below for the characteristics and functions, when known, for the 15 potential constituents, which are listed with functional information in the left hand column of this entry (McBride and Zhu 2013). Veith et al. 2017 have reviewed these T9SSs, and describe 18 (or 19) constituents including regulatory proteins.

Bacteria
Bacteroidota
T9SS of Porphyromonas gingivalis       
SprA, Sov, 2316 aas, forms a 32 stranded β-barrel and is likely to be the channel for the folded protein substrates. Q7MW38
Uncharacterized 8 stranded OM β-barrel protein of 235 aas; associated with PorK and PorN. Q7MXJ5
Putative OM lipoprotein of 827 aas. Multiple copies in some bacteria. Q7MWR1
Predicted TonB-dependent receptor; lipoprotein of 491 aas. Q7MXB7
PorK, GldK, OM lipoprotein of 346 aas. Forms large periplasmic rings with PorN. Q7MXB6
PorL, GldL, IM protein of 516 aas and 2 TMSs. Interacts with PorM and PorX. Q7MXB5
PorM, GldM, IM protein of 361 aas with periplasmic domains. Interacts with PorL, PorK and PlrN. Q7MXB4
PorN, GldN, forms large periplasmic rings with PorK. B2RLE7
GldO, Paralog of PorN; not present in P gingivalis. Both GldN and GldO need to be disrupted to cause loss of motility in F. johnsoniae. Q7MXB8
PorP, SprF, SprP, predicted OM β-barrel protein of 346 aas with multiple copies in some bacteria. Q7MWK8
PorQ, predicted 14 stranded OM β-barrel protein of193 aas, like FadL. Binds PorZ. Q7MXL2
PorT, SprT, predicted 8 stranded OM β-barrel protein of 1123 aas. Q7MXX2
PorU, Predicted C25 protease (gingipain) of 391 aas.  Contains an uncleaved T9SS signal.  May be the T9SS sortase. Binds PorV. Q7MXX1
PorV, LptO, Predicted 14 stranded OM β-barrel protein of 1160 aas; like FadL.  Binds T9SS substrates including PorU.  May be a shuttle protein.
PorW, SprE, predicted lipoprotein with TPR repeats, of 518 aas. Q7MVV4
2.A.130.1.2









The Type 9 secretion system with 6 components, SprA, SprE, SprT, GldK, GldL and GldM.

Bacteria
Bacteroidota
6 components of the T9SS of Flavobacterium johnsoniae (Cytophaga johnsonae)
GldK (464 aas; 1TMS) (Q5EGM5)
GldL (215 aas; 2TMSs) (Q5EGM4)
GldR1 (513 aas; 1TMS) (Q5EGM3)
SprA (2,403 aas; 1TMS) (Q5I6C7)
SprE (870 aas; 1TMS) (A1E5T9)
SprT (237 aas; 1TMS) (A5FJX0)