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2.A.16.1.2
Tellurite resistance protein TehA homologue. An anion channel involved in tellurite resistance.  A quasi-symmetrical homotrimer in which each subunit has 10 TMSs and forms a channel.  The crystal structure is known at 1.2 A resolution (Chen et al. 2010).  The helices are arranged from helical hairpin pairs to form a central 5-helix transmembrane pore that is gated by a conserved phenylalanine residue.  Gating is controlled by kinase activation.  Selectivity for various anions may be a function of the energetic cost of ion dehydration (Chen et al. 2010).

Accession Number:P44741
Protein Name:Tellurite resistance protein tehA homologue
Length:328
Molecular Weight:36934.00
Species:Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [71421]
Number of TMSs:10
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate Tellurite, anions

Cross database links:

DIP: DIP-59222N
Entrez Gene ID: 950588   
Pfam: PF03595   
KEGG: hin:HI0511   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005216 F:ion channel activity
GO:0046677 P:response to antibiotic
GO:0046690 P:response to tellurium ion

References (2)

[1] “Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.”  Fleischmann R.D.et.al.   7542800
[2] “Homologue structure of the SLAC1 anion channel for closing stomata in leaves.”  Chen Y.H.et.al.   20981093
Structure:
3M71   3M72   3M73   3M74   3M75   3M76   3M77   3M78   3M7B   3M7C   [...more]

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLHFAHIFQN KVHTMNITKP FPLPTGYFGI PLGLAALSLA WFHLENLFPA ARMVSDVLGI 
61:	VASAVWILFI LMYAYKLRYY FEEVRAEYHS PVRFSFIALI PITTMLVGDI LYRWNPLIAE 
121:	VLIWIGTIGQ LLFSTLRVSE LWQGGVFEQK STHPSFYLPA VAANFTSASS LALLGYHDLG 
181:	YLFFGAGMIA WIIFEPVLLQ HLRISSLEPQ FRATMGIVLA PAFVCVSAYL SINHGEVDTL 
241:	AKILWGYGFL QLFFLLRLFP WIVEKGLNIG LWAFSFGLAS MANSATAFYH GNVLQGVSIF 
301:	AFVFSNVMIG LLVLMTIYKL TKGQFFLK