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Accession Number: | P43007 |
Protein Name: | SATT aka AscT1 aka SLC1A4 |
Length: | 532 |
Molecular Weight: | 55723.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 10 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | sodium(1+), alanine, serine, cysteine, L-threonine |
Cross database links:
RefSeq: | NP_001129053.1 NP_003029.2 |
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Entrez Gene ID: | 6509 |
Pfam: | PF00375 |
OMIM: |
600229 gene |
KEGG: | hsa:6509 hsa:6509 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0005882
C:intermediate filament
GO:0042470
C:melanosome
GO:0005254
F:chloride channel activity
GO:0015180
F:L-alanine transmembrane transporter activity
GO:0015184
F:L-cystine transmembrane transporter activity
GO:0034590
F:L-hydroxyproline transmembrane transporter ...
GO:0015193
F:L-proline transmembrane transporter activity
GO:0015194
F:L-serine transmembrane transporter activity
GO:0015195
F:L-threonine transmembrane transporter activity
GO:0017153
F:sodium:dicarboxylate symporter activity
GO:0050890
P:cognition
GO:0006835
P:dicarboxylic acid transport
GO:0034589
P:hydroxyproline transport
GO:0015808
P:L-alanine transport
GO:0015811
P:L-cystine transport
GO:0015825
P:L-serine transport
GO:0015824
P:proline transport
GO:0035249
P:synaptic transmission, glutamatergic
GO:0015826
P:threonine transport
GO:0015186
F:L-glutamine transmembrane transporter activity
GO:0034590
F:L-hydroxyproline transmembrane transporter activity
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References (17)[1] “Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.” Arriza J.L.et.al. 8101838 [2] “Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.” Shafqat S.et.al. 8340364 [3] “Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15.” Hofmann K.et.al. 7896285 [4] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.” Chi A.et.al. 17081065 [7] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [8] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.” Wollscheid B.et.al. 19349973 [9] “Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.” Arriza J.L.et.al. 8101838 [10] “Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.” Shafqat S.et.al. 8340364 [11] “Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15.” Hofmann K.et.al. 7896285 [12] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [13] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MEKSNETNGY LDSAQAGPAA GPGAPGTAAG RARRCAGFLR RQALVLLTVS GVLAGAGLGA 61: ALRGLSLSRT QVTYLAFPGE MLLRMLRMII LPLVVCSLVS GAASLDASCL GRLGGIAVAY 121: FGLTTLSASA LAVALAFIIK PGSGAQTLQS SDLGLEDSGP PPVPKETVDS FLDLARNLFP 181: SNLVVAAFRT YATDYKVVTQ NSSSGNVTHE KIPIGTEIEG MNILGLVLFA LVLGVALKKL 241: GSEGEDLIRF FNSLNEATMV LVSWIMWYVP VGIMFLVGSK IVEMKDIIVL VTSLGKYIFA 301: SILGHVIHGG IVLPLIYFVF TRKNPFRFLL GLLAPFATAF ATCSSSATLP SMMKCIEENN 361: GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVE LNAGQIFTIL VTATASSVGA 421: AGVPAGGVLT IAIILEAIGL PTHDLPLILA VDWIVDRTTT VVNVEGDALG AGILHHLNQK 481: ATKKGEQELA EVKVEAIPNC KSEEETSPLV THQNPAGPVA SAPELESKES VL