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Accession Number: | Q15758 |
Protein Name: | AAAT aka System B° aka ATB° aka NBB aka SLC1A5 aka ASCT2 aka RDRC aka RDR aka M7V1 |
Length: | 541 |
Molecular Weight: | 56598.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 10 |
Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
Substrate | sodium(1+), amino acid |
Cross database links:
RefSeq: | NP_005619.1 |
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Entrez Gene ID: | 6510 |
Pfam: | PF00375 |
OMIM: |
109190 gene |
KEGG: | hsa:6510 |
Gene Ontology
GO:0005887
C:integral to plasma membrane
GO:0042470
C:melanosome
GO:0005624
C:membrane fraction
GO:0015175
F:neutral amino acid transmembrane transporte...
GO:0005515
F:protein binding
GO:0004872
F:receptor activity
GO:0017153
F:sodium:dicarboxylate symporter activity
GO:0006835
P:dicarboxylic acid transport
GO:0015804
P:neutral amino acid transport
GO:0005794
C:Golgi apparatus
GO:0015186
F:L-glutamine transmembrane transporter activity
GO:0006811
P:ion transport
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References (25)[1] “Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line.” Kekuda R.et.al. 8702519 [2] “The RD114/simian type D retrovirus receptor is a neutral amino acid transporter.” Rasko J.E.J.et.al. 10051606 [3] “A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses.” Tailor C.S.et.al. 10196349 [4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [6] “Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons.” Tailor C.S.et.al. 11350958 [7] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [8] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.” Chi A.et.al. 17081065 [9] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 [10] “Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.” Gauci S.et.al. 19413330 [11] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.” Wollscheid B.et.al. 19349973 [12] “Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.” Mayya V.et.al. 19690332 [13] “Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line.” Kekuda R.et.al. 8702519 [14] “The RD114/simian type D retrovirus receptor is a neutral amino acid transporter.” Rasko J.E.J.et.al. 10051606 [15] “A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses.” Tailor C.S.et.al. 10196349 [16] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [17] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [18] “Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons.” Tailor C.S.et.al. 11350958 [19] “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.” Olsen J.V.et.al. 17081983 [20] “Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.” Chi A.et.al. 17081065 [21] “A quantitative atlas of mitotic phosphorylation.” Dephoure N.et.al. 18669648 | |
Structure: | |
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Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MVADPPRDSK GLAAAEPTAN GGLALASIED QGAAAGGYCG SRDQVRRCLR ANLLVLLTVV 61: AVVAGVALGL GVSGAGGALA LGPERLSAFV FPGELLLRLL RMIILPLVVC SLIGGAASLD 121: PGALGRLGAW ALLFFLVTTL LASALGVGLA LALQPGAASA AINASVGAAG SAENAPSKEV 181: LDSFLDLARN IFPSNLVSAA FRSYSTTYEE RNITGTRVKV PVGQEVEGMN ILGLVVFAIV 241: FGVALRKLGP EGELLIRFFN SFNEATMVLV SWIMWYAPVG IMFLVAGKIV EMEDVGLLFA 301: RLGKYILCCL LGHAIHGLLV LPLIYFLFTR KNPYRFLWGI VTPLATAFGT SSSSATLPLM 361: MKCVEENNGV AKHISRFILP IGATVNMDGA ALFQCVAAVF IAQLSQQSLD FVKIITILVT 421: ATASSVGAAG IPAGGVLTLA IILEAVNLPV DHISLILAVD WLVDRSCTVL NVEGDALGAG 481: LLQNYVDRTE SRSTEPELIQ VKSELPLDPL PVPTEEGNPL LKHYRGPAGD ATVASEKESV 541: M