2.A.29.1.1
Mitochondrial ATP/ADP antiporter 2 (SLC25A5; ANT2) of 298 aas and 6 TMSs; it facilitates exchange of ADP and ATP between the cytosol and mitochondrial matrix (inhibited by carboxyatractyloside and bongkrekate) (Clémençon et al. 2013).  Modification of lysyl residues with fluorescamine induces Ca²⁺ permeability (Buelna-Chontal et al. 2014). Ca²⁺ induces oxidative stress, which increases lipid peroxidation and ROS generation, collapses the transmembrane potential and releases cytochrome c (Correa et al. 2018). Thus, pore opening in the inner mitochondrial membrane results from the binding of Ca²⁺ to the adenine nucleotide translocase. It is methylated by FAM173A, a mitochondrial lysine-specific methyltransferase that targets ANTs 2 and 3, and affects mitochondrial respiration (Małecki et al. 2019).