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Accession Number: | O75746 |
Protein Name: | CMC1 aka SLC25A12 aka ARALAR1 |
Length: | 678 |
Molecular Weight: | 74762.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 3 |
Location1 / Topology2 / Orientation3: | Mitochondrion inner membrane1 / Multi-pass membrane protein2 |
Substrate | glutamate(2-), aspartate(2-) |
Cross database links:
RefSeq: | NP_003696.2 |
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Entrez Gene ID: | 8604 |
Pfam: | PF00153 |
OMIM: |
603667 gene |
KEGG: | hsa:8604 hsa:8604 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005743
C:mitochondrial inner membrane
GO:0005509
F:calcium ion binding
GO:0015183
F:L-aspartate transmembrane transporter activity
GO:0005313
F:L-glutamate transmembrane transporter activity
GO:0005515
F:protein binding
GO:0015810
P:aspartate transport
GO:0015813
P:L-glutamate transport
GO:0043490
P:malate-aspartate shuttle
GO:0051592
P:response to calcium ion
GO:0055085
P:transmembrane transport
GO:0006094
P:gluconeogenesis
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References (12)[1] “Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain.” Del Arco A.et.al. 9722566 [2] “Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria.” Palmieri L.et.al. 11566871 [3] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein.” Kobayashi K.et.al. 10369257 [6] “Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain.” Del Arco A.et.al. 9722566 [7] “Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria.” Palmieri L.et.al. 11566871 [8] “Generation and annotation of the DNA sequences of human chromosomes 2 and 4.” Hillier L.W.et.al. 15815621 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MAVKVQTTKR GDPHELRNIF LQYASTEVDG ERYMTPEDFV QRYLGLYNDP NSNPKIVQLL 61: AGVADQTKDG LISYQEFLAF ESVLCAPDSM FIVAFQLFDK SGNGEVTFEN VKEIFGQTII 121: HHHIPFNWDC EFIRLHFGHN RKKHLNYTEF TQFLQELQLE HARQAFALKD KSKSGMISGL 181: DFSDIMVTIR SHMLTPFVEE NLVSAAGGSI SHQVSFSYFN AFNSLLNNME LVRKIYSTLA 241: GTRKDVEVTK EEFAQSAIRY GQVTPLEIDI LYQLADLYNA SGRLTLADIE RIAPLAEGAL 301: PYNLAELQRQ QSPGLGRPIW LQIAESAYRF TLGSVAGAVG ATAVYPIDLV KTRMQNQRGS 361: GSVVGELMYK NSFDCFKKVL RYEGFFGLYR GLIPQLIGVA PEKAIKLTVN DFVRDKFTRR 421: DGSVPLPAEV LAGGCAGGSQ VIFTNPLEIV KIRLQVAGEI TTGPRVSALN VLRDLGIFGL 481: YKGAKACFLR DIPFSAIYFP VYAHCKLLLA DENGHVGGLN LLAAGAMAGV PAASLVTPAD 541: VIKTRLQVAA RAGQTTYSGV IDCFRKILRE EGPSAFWKGT AARVFRSSPQ FGVTLVTYEL 601: LQRWFYIDFG GLKPAGSEPT PKSRIADLPP ANPDHIGGYR LATATFAGIE NKFGLYLPKF 661: KSPSVAVVQP KAAVAATQ