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2.A.29.14.6
Solute carrier family 25, member 40, SLC25A40 of 338 aas and 6 TMSs.  This mitochondrial inner membrane transporter can be mutated (Y125C) to give hypertriglyceridemia (Rosenthal et al. 2013).  It may also be involved in  primary Sjögren's syndrome (pSS), a prevalent and disabling form of fatigue (Norheim et al. 2014).  SLC25A40 facilitates anticancer drug resistance in human leukemia K562 cells (Kudo et al. 2023).

Accession Number:Q8TBP6
Protein Name:Solute carrier family 25 member 40
Length:338
Molecular Weight:38125.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate drug

Cross database links:

Entrez Gene ID: 55972   
Pfam: PF00153   
KEGG: hsa:55972    hsa:55972   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0055085 P:transmembrane transport

References (10)

[1] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[2] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[3] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250
[6] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[7] “The DNA sequence of human chromosome 7.”  Hillier L.W.et.al.   12853948
[8] “Human chromosome 7: DNA sequence and biology.”  Scherer S.W.et.al.   12690205
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MDPETRGQEI IKVTPLQQML ASCTGAILTS VIVTPLDVVK IRLQAQNNPL PKGKCFVYSN 
61:	GLMDHLCVCE EGGNKLWYKK PGNFQGTLDA FFKIIRNEGI KSLWSGLPPT LVMAVPATVI 
121:	YFTCYDQLSA LLRSKLGENE TCIPIVAGIV ARFGAVTVIS PLELIRTKMQ SKKFSYVELH 
181:	RFVSKKVSED GWISLWRGWA PTVLRDVPFS AMYWYNYEIL KKWLCEKSGL YEPTFMINFT 
241:	SGALSGSFAA VATLPFDVVK TQKQTQLWTY ESHKISMPLH MSTWIIMKNI VAKNGFSGLF 
301:	SGLIPRLIKI APACAIMIST YEFGKAFFQK QNVRRQQY