TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


2.A.29.14.7
solute carrier family 25, member 44, SLC25A44 of 314 aas and 6 TMSs in a 3 + 3 arrangement. The GBA-370Rec Parkinson's disease risk haplotype harbors a potentially pathogenic variant in the SLC25A44 mitochondrial gene (Goldstein et al. 2021).

Accession Number:Q96H78
Protein Name:Solute carrier family 25 member 44
Length:314
Molecular Weight:35392.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

Entrez Gene ID: 9673   
Pfam: PF00153   
KEGG: hsa:9673    hsa:9673   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005488 F:binding
GO:0055085 P:transmembrane transport

References (10)

[1] “Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.”  Seki N.et.al.   9455484
[2] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[3] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250
[6] “Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.”  Seki N.et.al.   9455484
[7] “Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.”  Otsuki T.et.al.   16303743
[8] “The DNA sequence and biological annotation of human chromosome 1.”  Gregory S.G.et.al.   16710414
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system.”  Haitina T.et.al.   16949250

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MEDKRNIQII EWEHLDKKKF YVFGVAMTMM IRVSVYPFTL IRTRLQVQKG KSLYHGTFDA 
61:	FIKILRADGI TGLYRGFLVN TFTLISGQCY VTTYELTRKF VADYSQSNTV KSLVAGGSAS 
121:	LVAQSITVPI DVVSQHLMMQ RKGEKMGRFQ VRGNPEGQGV VAFGQTKDII RQILQADGLR 
181:	GFYRGYVASL LTYIPNSAVW WPFYHFYAEQ LSYLCPKECP HIVFQAVSGP LAAATASILT 
241:	NPMDVIRTRV QVEGKNSIIL TFRQLMAEEG PWGLMKGLSA RIISATPSTI VIVVGYESLK 
301:	KLSLRPELVD SRHW