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2.A.29.18.3 Solute carrier family 25 (S-adenosylmethionine (SAM) carrier), member 26 of 275 aas and 6 TMSs. It is responsible for the uptake of SAM into mitochondria and when defective by mutation gives rise to combined oxidative phosphorylation deficiency 28 (COXPD28) (Ji et al. 2021).
Accession Number:	Q70HW3
Protein Name:	S-adenosylmethionine mitochondrial carrier protein
Length:	274
Molecular Weight:	29381.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	4
Location¹ / Topology² / Orientation³:	Mitochondrion inner membrane¹ / Multi-pass membrane protein²
Substrate	S-adenosyl-L-methionine

Entrez Gene ID:	115286
Pfam:	PF00153
KEGG:	hsa:115286 hsa:115286
Gene Ontology GO:0016021 C:integral to membrane GO:0005743 C:mitochondrial inner membrane GO:0005634 C:nucleus GO:0000095 F:S-adenosylmethionine transmembrane transporter activity
References (6) [1] “Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution.” Agrimi G.et.al. 14674884 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution.” Agrimi G.et.al. 14674884 [5] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334

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FASTA formatted sequence

1:	MDRPGFVAAL VAGGVAGVSV DLILFPLDTI KTRLQSPQGF NKAGGFHGIY AGVPSAAIGS 
61:	FPNAAAFFIT YEYVKWFLHA DSSSYLTPMK HMLAASAGEV VACLIRVPSE VVKQRAQVSA 
121:	STRTFQIFSN ILYEEGIQGL YRGYKSTVLR EIPFSLVQFP LWESLKALWS WRQDHVVDSW 
181:	QSAVCGAFAG GFAAAVTTPL DVAKTRITLA KAGSSTADGN VLSVLHGVWR SQGLAGLFAG 
241:	VFPRMAAISL GGFIFLGAYD RTHSLLLEVG RKSP

2.A.29.18.3
Solute carrier family 25 (S-adenosylmethionine (SAM) carrier), member 26 of 275 aas and 6 TMSs. It is responsible for the uptake of SAM into mitochondria and when defective by mutation gives rise to combined oxidative phosphorylation deficiency 28 (COXPD28) (Ji et al. 2021).

Cross database links:

Gene Ontology

References (6)

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2.A.29.18.3Solute carrier family 25 (S-adenosylmethionine (SAM) carrier), member 26 of 275 aas and 6 TMSs. It is responsible for the uptake of SAM into mitochondria and when defective by mutation gives rise to combined oxidative phosphorylation deficiency 28 (COXPD28) (Ji et al. 2021).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.29.18.3
Solute carrier family 25 (S-adenosylmethionine (SAM) carrier), member 26 of 275 aas and 6 TMSs. It is responsible for the uptake of SAM into mitochondria and when defective by mutation gives rise to combined oxidative phosphorylation deficiency 28 (COXPD28) (Ji et al. 2021).