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| Accession Number: | Q9BXI2 |
| Protein Name: | Mitochondrial ornithine transporter 2 aka Solute carrier family 25, member 2 |
| Length: | 301 |
| Molecular Weight: | 32580.00 |
| Species: | Homo sapiens (Human) [9606] |
| Number of TMSs: | 5 |
| Location1 / Topology2 / Orientation3: | Mitochondrion inner membrane1 / Multi-pass membrane protein2 |
| Substrate | hydron, lysine, ornithine, citrulline, arginine, histidine |
Cross database links:
| RefSeq: | NP_114153.1 |
|---|---|
| Entrez Gene ID: | 83884 |
| Pfam: | PF00153 |
| OMIM: |
608157 gene |
| KEGG: | hsa:83884 hsa:83884 hsa:83884 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005743
C:mitochondrial inner membrane
GO:0005488
F:binding
GO:0000064
F:L-ornithine transmembrane transporter activity
GO:0000066
P:mitochondrial ornithine transport
GO:0055085
P:transmembrane transport
GO:0000050
P:urea cycle
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References (9)[1] “Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.” Wu Q.et.al. 11230163 [2] “Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder.” Camacho J.A. IIIet.al. 12948741 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.” Wu Q.et.al. 11230163 [5] “Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder.” Camacho J.A. IIIet.al. 12948741 [6] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [7] “Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.” Wu Q.et.al. 11230163 [8] “Cloning and characterization of human ORNT2: a second mitochondrial ornithine transporter that can rescue a defective ORNT1 in patients with the hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, a urea cycle disorder.” Camacho J.A. IIIet.al. 12948741 [9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MKSGPGIQAA IDLTAGAAGG TACVLTGQPF DTIKVKMQTF PDLYKGLTDC FLKTYAQVGL 61: RGFYKGTGPA LMAYVAENSV LFMCYGFCQQ FVRKVAGMDK QAKLSDLQTA AAGSFASAFA 121: ALALCPTELV KCRLQTMYEM EMSGKIAKSH NTIWSVVKGI LKKDGPLGFY HGLSSTLLQE 181: VPGYFFFFGG YELSRSFFAS GRSKDELGPV HLMLSGGVAG ICLWLVVFPV DCIKSRIQVL 241: SMYGKQAGFI GTLLSVVRNE GIVALYSGLK ATMIRAIPAN GALFVAYEYS RKMMMKQLEA 301: Y