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2.A.29.2.6
Plant dicarboxylate/tricarboxylate carrier, DTC, transports dicarboxylates (such as malate, oxaloacetate, oxoglutarate, and maleate) and tricarboxylates (such as citrate, isocitrate, cis-aconitate, and trans-aconitate)

Accession Number:Q8SF04
Protein Name:DTC aka DTC1
Length:297
Molecular Weight:31681.00
Species:Nicotiana tabacum (Common tobacco) [4097]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate citrate salt, oxaloacetate(2-), malate(2-), maleate(2-), cis-aconitate(3-), trans-aconitate(3-), isocitrate(3-), 2-oxoglutaric acid

Cross database links:

Pfam: PF00153   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005739 C:mitochondrion
GO:0005488 F:binding
GO:0055085 P:transmembrane transport

References (1)

[1] “Identification of a novel transporter for dicarboxylates and tricarboxylates in plant mitochondria. Bacterial expression, reconstitution, functional characterization, and tissue distribution.”  Picault N.et.al.   11978797

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGEKPKSGGV WPTVKPFVNG GASGMLATCV IQPIDMIKVR IQLGQGSAVD VTKTMLKNEG 
61:	FGAFYKGLSA GLLRQATYTT ARLGSFRSLT NKAIEANEGK PLPLYQKALC GLTAGAIGAC 
121:	VGSPADLALI RMQADATLPL AQRRHYTNAF HALSRIVADE GVLALWKGAG PTVVRAMALN 
181:	MGMLASYDQS VEFCRDNLGM SEAATVVGAS SVSGFFAAAC SLPFDYVKTQ IQKMQPDAEG 
241:	KLPYSGSFDC AMKTLKAGGP FKFYTGFPVY CVRIAPHVMM TWIFLNQIQK AEKKLGL