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2.A.29.23.5
Solute carrier family 25 (mitochondrial carrier; ATP-M2+/phosphate carrier), member 23 of 468 aas and 6 TMSs, SLC25A23, APC2, MCSC2, SCaMC-3.  Variants are generated by alternative splicing (Del Arco 2005; Bassi et al. 2005).  Glucagon regulation of oxidative phosphorylatioin requires an increase in matrix adenine nucleotides involving SCaMC-3 (Amigo et al. 2013). SLC25A23 augments mitochondrial Ca2+ uptake, interacts with MCU, and induces oxidative stress-mediated cell death (Hoffman et al. 2014). It also counteracts the PARP-1-dependent fall in mitochondrial ATP caused by excitotoxic insults in neurons (Rueda et al. 2015). CaMCs play a role in glutamate excitotoxicity and Ca2+ regulation of respiration (Rueda et al. 2016).

Accession Number:Q9BV35
Protein Name:Calcium-binding mitochondrial carrier protein SCaMC-3
Length:468
Molecular Weight:52378.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion inner membrane1 / Multi-pass membrane protein2
Substrate phosphate(3-)

Cross database links:

Entrez Gene ID: 79085   
Pfam: PF00153   
KEGG: hsa:79085    hsa:79085   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005743 C:mitochondrial inner membrane
GO:0005509 F:calcium ion binding
GO:0055085 P:transmembrane transport

References (12)

[1] “Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains.”  del Arco A.et.al.   15054102
[2] “Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution.”  Fiermonte G.et.al.   15123600
[3] “Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family.”  Bassi M.T.et.al.   15716113
[4] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[6] “Novel variants of human SCaMC-3, an isoform of the ATP-Mg/P(i) mitochondrial carrier, generated by alternative splicing from 3'-flanking transposable elements.”  Del Arco A.et.al.   15801905
[7] “Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains.”  del Arco A.et.al.   15054102
[8] “Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution.”  Fiermonte G.et.al.   15123600
[9] “Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene family.”  Bassi M.T.et.al.   15716113
[10] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[11] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[12] “Novel variants of human SCaMC-3, an isoform of the ATP-Mg/P(i) mitochondrial carrier, generated by alternative splicing from 3'-flanking transposable elements.”  Del Arco A.et.al.   15801905

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MRGSPGDAER RQRWGRLFEE LDSNKDGRVD VHELRQGLAR LGGGNPDPGA QQGISSEGDA 
61:	DPDGGLDLEE FSRYLQEREQ RLLLMFHSLD RNQDGHIDVS EIQQSFRALG ISISLEQAEK 
121:	ILHSMDRDGT MTIDWQEWRD HFLLHSLENV EDVLYFWKHS TVLDIGECLT VPDEFSKQEK 
181:	LTGMWWKQLV AGAVAGAVSR TGTAPLDRLK VFMQVHASKT NRLNILGGLR SMVLEGGIRS 
241:	LWRGNGINVL KIAPESAIKF MAYEQIKRAI LGQQETLHVQ ERFVAGSLAG ATAQTIIYPM 
301:	EVLKTRLTLR RTGQYKGLLD CARRILEREG PRAFYRGYLP NVLGIIPYAG IDLAVYETLK 
361:	NWWLQQYSHD SADPGILVLL ACGTISSTCG QIASYPLALV RTRMQAQASI EGGPQLSMLG 
421:	LLRHILSQEG MRGLYRGIAP NFMKVIPAVS ISYVVYENMK QALGVTSR